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GO:0004222: metalloendopeptidase activity (Molecular function)

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


There are 6858 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_34 Arabidopsis thaliana 2.5 % 0.002768 0.008926
Cluster_185 Arabidopsis thaliana 1.44 % 0.008108 0.021719
Cluster_256 Amborella trichopoda 3.64 % 0.002957 0.047039
Cluster_197 Amborella trichopoda 3.23 % 0.000345 0.008897
Cluster_244 Amborella trichopoda 3.23 % 0.003741 0.020915
Cluster_98 Cyanophora paradoxa 3.28 % 0.001108 0.047254
Cluster_79 Cyanophora paradoxa 2.11 % 0.002658 0.036504
Cluster_182 Cyanophora paradoxa 6.12 % 8e-06 0.00089
Cluster_192 Gingko biloba 4.0 % 0.000458 0.016375
Cluster_151 Gingko biloba 2.35 % 0.001317 0.008482
Cluster_135 Gingko biloba 3.39 % 0.000638 0.012485
Cluster_208 Zea mays 1.92 % 8.7e-05 0.001886
Cluster_319 Zea mays 4.23 % 8e-06 0.000804
Cluster_112 Marchantia polymorpha 4.23 % 0.00016 0.012464
Cluster_178 Marchantia polymorpha 3.12 % 0.004098 0.030649
Cluster_65 Marchantia polymorpha 1.95 % 0.000233 0.001716
Cluster_88 Picea abies 1.6 % 0.001774 0.042143
Cluster_51 Picea abies 4.71 % 0.0 1e-06
Cluster_324 Oryza sativa 4.26 % 0.000451 0.00933
Cluster_189 Oryza sativa 1.14 % 0.006024 0.04217
Cluster_638 Oryza sativa 50.0 % 0.001327 0.014265
Cluster_88 Selaginella moellendorffii 1.69 % 0.002648 0.022239
Cluster_25 Solanum lycopersicum 1.18 % 0.012502 0.0287
Cluster_160 Solanum lycopersicum 1.96 % 0.004676 0.04311
Sequences (6858) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro and Family associations disabled for items with more than 5000 associated sequences !