1. Home
  2. GO
  3. GO:0007186

GO:0007186: G-protein coupled receptor signaling pathway (Biological process)

"A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]


There are 4230 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_178 Amborella trichopoda 3.85 % 0.000367 0.012859
Cluster_215 Cyanophora paradoxa 4.0 % 8.4e-05 0.009802
Cluster_332 Gingko biloba 5.0 % 0.0 1.1e-05
Cluster_91 Physcomitrella patens 1.54 % 0.002003 0.025175
Cluster_453 Picea abies 2.86 % 4.9e-05 0.001915
Cluster_173 Solanum lycopersicum 0.96 % 0.004748 0.030861
Sequences (4230) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms