Heatmap: Cluster_190 (HCCA)

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(Showing raw values)

Gene
Aerial tissue - Light - ZT1
Aerial tissue - Light - ZT3
Aerial tissue - Light - ZT5
Aerial tissue - Light - ZT7
Aerial tissue - Light - ZT9
Aerial tissue - Light - ZT11
Aerial tissue - Dark - ZT1
Aerial tissue - Dark - ZT3
Aerial tissue - Dark - ZT5
Aerial tissue - Dark - ZT7
Aerial tissue - Dark - ZT9
Aerial tissue - Dark - ZT11
Roots
Root elongation and differentiation zone
Root meristematic zone
Aerial roots and rhizophores
Shoot tips
Microphyll
Strobili
Shoot apical meristem - AC
Shoot apical meristem - Core
Shoot apical meristem - P1
Stem - Top
Stem - Bottom
Whole plant
Aerial tissue - Stress - Dark
Aerial tissue - Stress - High light
Aerial tissue - Stress - Cont
Aerial tissue - Stress - 37C 1h
Aerial tissue - Stress - 37C 3h
Aerial tissue - Stress - 4C 1h
Aerial tissue - Stress - 4C 3h
3.36 4.61 4.24 2.86 2.74 3.62 2.44 3.45 3.0 4.23 3.7 3.51 3.06 18.26 13.0 11.6 1.64 1.4 4.01 4.93 1.23 0.07 1.38 1.43 6.23 3.17 3.86 4.07 2.49 1.9 1.19 0.93
43.78 49.3 50.43 52.18 57.76 56.03 43.65 48.15 42.26 39.44 42.67 42.7 62.48 112.6 108.49 74.76 29.46 39.71 46.43 23.5 26.17 11.49 46.65 46.39 39.57 53.5 44.36 50.13 28.56 30.01 21.08 17.92
62.35 72.04 73.53 78.16 68.59 77.38 75.97 80.38 79.49 78.42 73.85 72.26 93.36 174.6 139.02 86.72 58.33 52.03 65.3 33.25 35.24 15.54 64.5 73.31 91.18 107.6 95.75 90.32 50.52 55.76 50.34 48.09
29.46 30.48 31.79 28.72 32.35 32.53 31.02 33.19 32.32 31.44 30.57 26.27 46.85 44.71 39.4 60.26 21.02 17.26 43.01 5.11 6.22 5.67 27.49 40.23 14.72 49.06 38.63 43.92 22.49 26.48 17.17 20.43
44.01 41.05 35.28 39.85 44.39 37.66 40.4 43.17 41.4 47.81 45.14 42.48 53.25 63.1 68.21 57.94 24.94 24.67 52.27 7.78 5.98 16.74 36.56 42.87 38.87 66.75 47.14 50.04 28.8 31.26 35.11 41.57
63.81 61.49 58.9 55.73 57.05 52.69 45.03 50.29 47.04 51.02 53.15 50.62 50.68 79.11 49.65 69.21 35.02 20.5 67.48 6.48 18.26 3.61 56.96 64.15 44.67 72.16 53.02 66.05 36.99 42.9 26.69 27.65
121.26 106.05 101.42 114.85 109.21 111.11 124.27 128.35 153.81 145.31 148.41 130.34 98.38 231.78 272.17 96.55 108.45 100.35 133.78 11.48 38.28 13.99 83.42 93.95 86.44 134.05 124.7 131.11 119.49 128.69 104.11 102.1
246.78 282.53 272.81 268.29 273.22 253.77 276.44 285.26 301.76 305.36 299.16 282.23 327.95 446.14 332.61 330.13 182.45 151.07 260.28 72.88 107.47 43.42 268.03 284.82 202.41 388.82 258.3 265.72 191.58 199.92 208.32 231.95
104.17 119.09 136.23 166.57 161.33 179.38 172.5 192.04 172.69 156.26 148.1 134.67 157.65 278.58 198.8 168.41 104.42 91.55 137.24 39.99 70.4 31.4 143.45 141.17 163.8 251.65 247.5 253.34 99.74 105.98 101.06 114.86
42.91 46.29 49.78 55.06 56.29 54.42 46.68 60.05 54.68 55.94 51.06 46.49 61.37 101.09 43.82 72.31 27.94 21.09 57.51 5.82 13.99 5.31 51.2 58.96 26.3 84.63 64.58 63.46 34.19 33.84 29.38 32.87
170.38 192.11 186.34 206.02 196.36 193.66 220.6 209.61 213.27 207.43 181.1 188.03 287.63 355.18 289.94 300.6 150.38 166.79 268.26 132.94 140.9 77.02 250.17 257.21 244.57 228.42 154.71 149.79 162.34 160.59 190.94 192.43
171.94 178.75 195.5 192.62 199.3 219.07 177.2 174.32 182.76 172.5 181.06 155.12 289.89 379.86 196.38 313.33 137.26 132.35 169.99 121.05 43.04 88.74 197.28 219.19 72.63 251.77 290.75 309.44 136.31 145.3 138.28 124.83
121.68 115.38 132.77 162.34 172.65 171.64 189.52 191.83 192.76 165.19 153.14 135.95 160.57 349.62 275.62 163.76 104.15 91.48 140.43 28.63 71.7 32.71 101.05 110.71 207.86 138.99 213.93 191.15 105.39 113.46 136.93 146.66
59.26 60.35 63.35 64.47 73.74 71.4 68.84 75.45 69.4 71.19 71.15 58.75 113.64 118.31 112.47 120.35 50.31 44.74 89.78 19.33 22.8 9.65 74.54 88.11 64.15 122.56 104.52 116.67 57.5 60.19 45.77 37.28
165.63 171.41 181.22 188.7 189.63 194.43 180.09 179.07 181.11 178.66 159.22 154.17 191.54 460.74 392.63 173.66 117.39 123.92 162.37 52.69 101.19 70.82 134.53 157.57 216.07 163.91 224.19 214.07 105.15 118.75 104.45 116.96
20.29 19.76 18.6 20.04 20.58 20.19 17.04 20.12 19.18 19.55 19.01 17.48 26.08 31.91 27.0 28.97 13.44 11.07 22.72 6.42 6.32 3.0 17.03 18.29 16.84 26.49 27.83 27.82 13.27 14.15 14.68 14.7
99.7 79.88 85.02 80.87 85.95 81.3 78.63 89.21 85.59 90.72 86.84 79.02 155.37 253.58 178.3 162.28 56.57 46.58 78.43 7.79 25.14 5.44 64.78 72.53 48.48 158.09 108.65 109.44 57.98 59.39 53.56 50.48
69.98 74.09 58.26 64.13 61.47 57.27 52.69 49.14 47.15 48.11 47.44 46.83 91.97 137.18 130.06 117.22 45.32 35.72 80.15 3.04 6.05 0.96 48.65 51.63 13.21 89.42 118.47 107.19 38.13 42.9 97.02 74.66
45.89 44.37 41.99 41.15 43.96 41.48 41.71 44.86 44.93 44.59 42.33 45.26 53.96 67.77 56.71 58.67 29.31 22.67 48.37 9.33 17.75 6.69 40.0 51.13 39.34 71.96 71.03 66.19 32.61 37.73 24.46 27.19
300.92 334.41 350.76 347.47 324.14 331.6 336.31 335.55 353.12 351.58 334.08 316.66 576.29 796.58 496.09 588.18 303.17 311.33 340.69 196.1 151.68 128.85 465.14 501.78 572.88 362.95 342.3 291.99 308.47 323.34 428.61 434.29
24.18 24.42 26.93 38.15 42.53 40.95 31.1 31.28 30.25 29.97 29.32 26.82 37.1 35.45 37.48 32.54 23.62 13.34 32.91 5.33 5.89 2.4 33.24 35.1 9.88 50.96 44.53 47.3 17.14 18.86 16.2 17.34
29.39 24.95 24.77 29.56 31.14 30.12 30.99 33.05 32.46 36.35 30.08 25.63 33.51 37.46 47.86 33.34 20.89 17.0 29.57 9.71 8.3 10.33 20.96 23.8 44.77 35.53 46.12 48.11 23.98 26.75 17.93 21.33
39.44 43.2 50.62 58.93 60.4 56.43 59.91 75.42 71.39 65.05 59.5 47.84 64.82 88.95 66.62 68.49 46.74 32.09 47.09 2.11 2.34 1.06 75.77 69.96 12.99 101.33 77.24 80.5 46.18 50.06 48.19 61.11
30.2 37.17 37.15 36.58 42.15 34.54 29.04 27.15 26.74 27.97 27.64 24.2 46.39 72.51 50.74 56.03 23.14 20.34 28.86 0.71 9.84 7.35 32.14 32.02 12.45 31.11 45.91 48.85 18.47 19.38 20.43 24.43
81.88 88.29 80.17 85.08 83.54 76.36 74.14 79.9 67.39 70.07 70.48 66.54 81.97 124.75 114.43 99.75 62.48 48.86 68.93 7.62 9.56 7.34 74.13 72.33 17.39 108.1 127.12 131.98 59.02 61.75 54.61 51.3
90.74 99.9 90.46 104.67 104.31 107.69 96.68 93.23 84.66 80.75 78.56 78.87 116.16 143.93 120.46 130.88 76.23 50.19 104.74 21.66 21.27 32.85 104.92 110.65 128.93 136.8 159.9 158.29 70.16 77.05 61.4 57.51
48.27 45.25 41.95 49.63 49.41 51.84 53.57 53.03 55.46 51.1 48.93 46.21 41.3 92.46 107.64 55.57 42.1 26.76 37.45 6.02 31.21 11.4 54.79 53.97 66.47 49.83 65.98 67.2 38.24 39.12 50.7 44.56
8.2 8.98 10.95 13.85 15.77 13.31 11.14 17.36 12.22 12.22 12.47 10.03 26.16 37.23 34.17 30.82 5.39 3.77 22.33 0.86 6.74 0.42 7.45 10.48 7.02 26.44 24.14 26.27 6.95 7.68 5.44 2.84
7.63 7.55 6.93 7.63 8.15 8.02 7.29 8.19 9.31 7.37 7.74 6.16 10.38 13.66 6.58 10.75 6.07 3.52 5.97 0.44 4.24 1.3 7.59 8.64 6.39 11.5 12.84 10.81 5.36 5.89 4.38 4.52
166.91 180.55 171.46 200.5 189.04 192.31 207.56 225.96 235.31 234.55 236.69 228.02 246.8 453.49 328.03 267.28 123.23 112.39 180.19 99.08 105.77 26.6 165.11 190.68 214.31 360.38 281.49 274.45 132.4 139.96 139.76 155.83
100.96 100.52 113.19 103.49 108.55 110.12 107.33 103.58 98.2 118.52 86.99 94.85 232.06 221.09 156.92 211.58 119.77 129.17 127.77 106.72 80.18 27.96 150.86 158.16 147.91 130.12 129.97 111.58 117.45 110.41 162.14 164.11
43.72 60.73 52.44 60.33 52.99 44.11 41.68 40.76 43.87 40.54 38.53 41.15 94.7 89.61 104.36 125.08 43.96 22.15 32.07 27.98 9.11 11.51 33.59 34.37 25.28 52.11 48.4 57.85 27.98 33.02 21.18 20.43
75.07 86.4 75.91 84.01 84.05 79.03 74.44 70.68 73.22 70.68 68.94 71.13 87.76 100.64 84.29 99.51 54.29 41.67 90.67 26.17 50.91 35.41 80.59 89.48 94.73 100.47 98.27 114.17 58.78 66.12 45.95 44.72
77.75 70.83 77.23 84.55 84.9 80.78 67.42 78.63 80.06 80.05 76.22 70.66 114.73 219.89 181.31 101.21 37.4 23.75 54.23 38.21 41.42 12.99 58.21 71.82 87.44 71.54 59.2 59.82 37.08 40.74 34.25 38.27
123.09 111.77 101.19 116.88 108.19 103.55 115.17 109.02 116.28 121.68 115.29 122.33 135.22 205.35 221.93 136.21 85.31 56.27 125.58 70.34 40.95 80.11 100.62 110.94 86.78 206.52 139.43 148.67 88.77 94.4 64.89 62.35
66.9 68.24 66.59 75.29 71.46 79.37 61.65 68.23 76.44 75.53 79.17 64.75 82.4 184.39 76.25 105.09 53.16 41.07 87.93 31.37 42.37 2.47 70.38 67.63 107.04 62.24 99.72 95.76 51.74 57.87 66.33 68.55
2.07 3.98 2.27 1.83 4.06 3.44 3.66 2.1 2.63 2.8 2.49 2.85 3.5 17.24 11.37 10.83 2.11 0.84 1.97 3.24 0.0 0.0 0.65 0.89 0.56 2.41 2.2 2.35 2.11 2.12 0.98 1.28
54.93 55.14 52.11 57.34 61.61 57.59 66.97 68.98 66.07 62.58 56.59 51.34 122.03 117.74 102.18 76.35 36.49 43.07 54.82 17.86 22.18 34.4 43.15 48.33 50.41 76.94 62.15 59.13 39.15 40.86 31.23 30.9
2.32 2.51 2.73 2.64 2.38 2.39 2.27 1.72 2.51 1.97 1.86 1.52 4.82 4.81 5.76 5.42 1.76 0.2 1.68 0.19 0.18 0.0 2.35 2.1 0.15 1.73 2.0 2.32 1.85 2.1 1.23 0.91
46.09 46.35 50.74 51.99 50.38 52.87 56.19 55.35 46.57 42.71 44.35 40.43 36.49 90.8 45.01 34.11 40.46 21.17 35.24 11.99 28.45 11.17 36.85 38.8 32.21 70.24 95.54 98.86 39.46 40.63 38.1 28.67
0.84 0.59 0.64 1.64 1.3 1.48 1.61 1.44 1.71 1.26 1.37 0.88 2.8 7.84 4.43 3.98 0.21 0.07 1.75 0.16 0.0 0.0 0.46 0.52 0.08 1.29 1.77 2.24 0.39 0.46 0.26 0.34
27.41 30.51 27.4 29.36 30.46 31.93 27.32 33.58 28.05 26.57 27.63 27.04 37.49 45.71 43.43 45.72 21.81 16.29 34.71 2.03 0.91 0.0 25.51 25.5 13.41 31.6 33.9 37.63 26.74 25.81 15.02 15.85
4.69 5.54 5.74 7.37 7.62 7.56 7.89 6.82 7.33 6.07 6.12 5.24 16.62 17.88 13.69 11.76 4.49 3.06 3.45 1.61 2.86 6.41 3.51 4.43 7.52 2.36 5.78 6.85 4.29 4.42 2.65 2.08
29.63 31.09 28.66 27.07 26.04 25.49 24.13 21.16 23.72 27.56 25.93 24.95 36.16 57.64 59.51 47.71 19.37 14.4 23.47 8.02 23.09 6.68 21.69 19.63 21.23 23.16 18.87 22.98 19.72 23.09 10.29 9.97
17.67 19.78 17.53 16.28 17.49 20.92 15.92 20.69 22.18 17.67 18.26 15.35 12.59 32.68 21.75 22.65 12.51 10.46 16.99 8.34 2.21 0.44 15.25 14.77 6.79 21.87 28.49 27.24 13.56 15.61 12.02 11.57
30.76 34.47 33.7 42.52 33.87 37.41 37.0 38.99 45.87 38.78 40.37 35.18 51.78 53.18 36.55 57.11 21.68 13.38 30.41 3.36 12.02 12.95 26.7 27.74 24.61 66.2 64.28 62.99 24.26 23.01 20.22 22.73
31.96 30.67 30.97 34.09 36.27 33.69 27.99 33.68 33.67 29.21 29.05 27.97 64.3 88.79 40.62 81.53 20.17 16.34 43.54 5.62 23.73 9.55 51.01 53.55 76.91 42.68 46.7 45.02 22.53 26.22 39.15 34.73
0.6 0.79 0.78 1.39 1.34 1.97 1.43 1.15 1.17 1.21 1.46 0.72 0.17 2.28 1.38 0.66 0.66 0.43 0.74 0.13 1.88 0.56 0.6 0.5 0.61 2.15 3.0 2.84 0.46 0.43 0.29 0.14
18.02 22.54 27.4 36.57 37.98 37.95 29.36 27.86 26.99 20.24 23.75 19.96 91.78 80.64 72.74 45.35 12.16 19.74 7.78 25.47 32.06 15.68 11.34 15.17 37.13 19.96 38.98 38.83 9.23 10.41 6.8 9.12
14.99 14.7 14.35 16.67 16.63 16.57 16.23 15.98 18.44 18.49 18.39 15.93 35.23 31.84 20.69 31.26 11.14 12.11 25.73 0.0 3.65 2.31 14.62 17.5 9.33 31.85 23.86 25.01 13.97 16.93 9.78 10.07
26.1 27.67 29.69 30.64 27.65 30.38 26.41 26.93 31.11 30.15 30.64 25.84 43.47 44.32 47.87 41.65 23.45 20.82 30.54 22.56 16.0 12.0 24.85 26.54 25.07 40.49 35.39 42.64 23.66 29.36 16.93 21.68
25.73 27.66 28.08 26.44 29.71 28.23 24.9 26.53 23.92 27.84 24.57 23.33 39.52 59.45 55.89 35.03 19.06 23.74 30.1 7.72 31.28 5.87 21.18 23.42 33.04 30.85 22.39 30.19 18.96 18.61 11.78 14.18
47.71 56.02 47.39 51.51 49.47 43.06 42.5 45.33 46.29 42.67 42.96 41.9 47.92 79.6 53.52 70.12 26.67 19.34 60.04 2.16 8.51 5.48 35.82 38.84 24.35 58.69 58.58 59.94 35.56 37.71 24.43 29.3
72.63 79.37 74.51 84.55 84.77 83.3 75.87 91.21 85.76 74.8 80.0 73.01 113.84 131.26 94.85 117.72 54.6 50.31 91.34 17.62 33.49 16.02 79.68 85.23 60.04 95.18 103.26 93.11 57.47 58.03 49.0 45.75
37.98 41.41 40.81 44.26 48.48 42.43 41.52 42.64 39.94 36.6 35.49 30.84 62.17 51.9 50.94 70.99 27.75 20.64 46.17 10.59 2.99 11.47 46.18 53.23 7.4 56.59 56.94 63.43 30.07 34.16 25.78 24.08
21.55 20.62 20.57 23.78 24.95 21.27 21.03 23.07 22.4 22.51 20.63 19.89 25.35 56.26 23.7 28.22 15.87 8.35 24.2 1.71 3.7 1.67 17.12 19.6 11.42 30.01 27.38 29.94 18.41 19.87 18.21 18.55
106.17 118.12 123.94 135.29 142.88 128.59 124.12 131.73 125.8 123.59 117.16 109.78 187.1 262.46 203.05 176.84 63.95 59.42 156.49 17.19 37.43 14.52 105.53 120.62 110.14 199.25 171.53 171.08 73.5 80.81 91.74 110.67
57.24 64.67 64.36 73.5 72.09 59.21 63.17 72.45 69.27 71.35 66.76 62.12 164.38 159.33 94.89 128.47 37.16 22.96 53.54 10.05 15.64 12.38 47.41 60.56 23.49 104.65 84.39 94.32 40.14 47.69 31.79 41.05
60.09 62.11 55.58 59.33 62.88 58.53 56.76 67.15 61.22 57.91 59.05 57.47 86.45 157.65 68.01 69.96 42.63 45.47 65.71 6.68 34.42 5.19 55.98 59.26 78.38 85.39 99.05 78.59 43.95 43.36 55.15 78.56
8.68 8.57 9.69 11.64 10.5 13.44 13.0 13.63 15.36 15.22 12.81 12.02 19.97 28.83 25.87 14.84 7.52 5.5 6.36 3.64 5.16 2.72 5.18 5.27 11.66 21.5 14.07 19.43 7.17 7.43 4.6 4.86
65.69 62.66 58.28 58.04 54.77 53.02 54.35 50.3 50.69 51.91 50.83 51.18 110.7 111.77 107.27 126.88 33.61 29.91 46.47 6.82 0.0 0.0 45.85 59.46 1.45 84.31 100.03 107.96 40.69 45.81 34.46 33.69
92.14 102.63 107.49 136.98 137.46 122.38 122.98 134.77 126.99 125.8 113.58 106.65 104.08 158.86 140.2 114.32 75.22 52.69 101.47 25.77 25.38 34.73 135.11 132.26 61.07 204.97 168.99 177.45 72.72 80.71 85.08 90.18
50.21 70.06 67.55 68.63 61.77 66.36 62.97 59.76 61.45 64.84 62.98 60.79 82.53 102.29 83.57 91.52 47.94 41.73 72.24 33.01 32.22 45.71 62.13 61.09 24.63 69.09 65.94 69.29 46.42 53.72 46.0 45.29
62.81 63.05 73.13 81.83 86.86 88.91 79.67 93.4 75.13 72.99 64.21 55.85 158.1 155.6 119.12 146.54 71.62 56.33 114.4 19.81 26.86 9.06 106.39 109.46 64.21 209.91 150.44 150.37 78.72 77.27 57.91 65.31
1.08 0.4 0.6 0.75 0.25 0.55 0.51 1.23 1.41 0.87 1.28 1.05 1.96 9.29 5.63 6.01 0.03 0.11 1.62 0.0 0.0 0.0 0.31 0.53 1.48 0.78 0.5 1.15 0.05 0.11 0.08 0.05
15.71 13.19 12.85 12.99 14.88 16.27 13.98 12.82 13.58 11.4 12.47 10.57 25.13 27.23 27.19 27.56 13.64 10.28 16.26 1.13 5.91 1.03 11.23 12.76 2.21 15.28 16.86 18.51 10.96 11.18 11.37 9.29
8.89 10.88 10.94 11.13 10.43 13.26 11.61 14.79 12.31 9.5 9.59 8.12 11.56 13.89 14.65 12.54 6.93 6.3 12.33 3.66 2.86 2.53 7.98 9.52 13.77 17.86 17.69 17.43 7.82 8.12 5.23 7.32
36.46 36.06 47.36 55.72 66.14 70.71 70.11 75.28 57.47 60.88 52.72 44.0 48.48 83.95 80.16 43.27 36.74 30.28 46.01 12.63 8.78 8.01 54.4 68.43 71.45 67.8 92.73 100.79 38.61 43.77 33.7 35.88
39.34 39.22 39.96 39.79 42.52 36.61 39.48 42.82 41.83 37.58 43.09 34.86 75.74 73.26 57.65 94.1 28.67 30.4 48.39 3.28 7.75 2.95 44.86 61.4 26.29 79.71 63.55 59.03 30.69 35.89 31.92 34.15
32.38 34.16 34.44 37.01 42.4 39.2 34.25 41.43 35.46 36.31 36.54 29.35 64.29 63.67 38.12 75.67 26.81 18.99 48.74 0.22 1.51 1.86 38.52 43.64 3.38 46.11 45.07 50.43 29.45 33.83 20.0 19.86
19.43 22.56 21.96 25.58 28.91 27.02 23.26 26.53 19.38 18.35 17.6 17.2 22.71 28.56 30.8 30.72 17.66 13.93 30.62 3.96 16.9 2.07 22.44 24.18 34.14 32.51 43.37 44.69 19.95 19.9 22.19 15.86
46.43 49.52 55.96 60.22 57.59 55.23 57.56 62.76 58.42 55.79 50.35 48.89 55.62 106.71 71.5 68.0 41.55 28.88 48.57 4.03 23.64 14.56 47.63 47.59 62.64 81.09 99.87 90.45 39.77 44.57 45.28 41.24
60.67 65.42 68.17 72.66 70.48 61.83 71.33 77.19 75.11 75.01 75.5 67.47 77.1 91.31 76.31 75.95 54.22 39.24 56.63 18.06 7.33 8.92 75.01 75.01 44.71 98.16 89.13 109.71 56.33 60.43 65.1 45.22
16.49 24.21 22.87 25.69 26.74 24.2 16.55 20.46 18.68 16.71 18.03 14.62 28.47 48.54 32.91 40.25 15.96 18.09 33.13 0.32 3.35 0.57 23.29 20.45 24.74 33.23 34.69 38.85 14.06 15.1 15.93 22.12
27.39 26.62 22.64 22.83 18.98 24.57 21.76 19.5 24.22 27.77 19.96 24.05 30.97 40.4 24.71 30.66 14.02 8.5 24.05 0.31 10.11 2.68 20.3 19.54 11.52 30.26 26.59 27.01 14.78 14.36 10.17 13.28
29.93 28.86 34.4 32.94 33.39 32.19 30.12 34.0 32.97 33.83 31.36 29.83 36.85 83.93 54.03 40.91 17.14 12.41 36.72 7.0 9.1 13.83 20.73 22.32 8.88 46.68 41.56 40.4 18.74 19.99 15.25 15.01

Details

Raw expression values (TPM normalized), Green cells indicate low expression and red high. (Dark gray cells indicate missing values)