Heatmap: Cluster_137 (HCCA)

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(Values are log2 transformed ratios of a genes expression in a sample divided by the mean expression level)

Gene
Synchronized diurnal culture 1h (CC-2895)
Synchronized diurnal culture 2h (CC-2895)
Synchronized diurnal culture 3h (CC-2895)
Synchronized diurnal culture 4h (CC-2895)
Synchronized diurnal culture 5h (CC-2895)
Synchronized diurnal culture 6h (CC-2895)
Synchronized diurnal culture 7h (CC-2895)
Synchronized diurnal culture 8h (CC-2895)
Synchronized diurnal culture 9h (CC-2895)
Synchronized diurnal culture 10h (CC-2895)
Synchronized diurnal culture 11h (CC-2895)
Synchronized diurnal culture 11.5h (CC-2895)
Synchronized diurnal culture 12h (CC-2895)
Synchronized diurnal culture 12.5h (CC-2895)
Synchronized diurnal culture 13h (CC-2895)
Synchronized diurnal culture 13.5h (CC-2895)
Synchronized diurnal culture 14h (CC-2895)
Synchronized diurnal culture 14.5h (CC-2895)
Synchronized diurnal culture 15h (CC-2895)
Synchronized diurnal culture 16h (CC-2895)
Synchronized diurnal culture 17h (CC-2895)
Synchronized diurnal culture 18h (CC-2895)
Synchronized diurnal culture 19h (CC-2895)
Synchronized diurnal culture 20h (CC-2895)
Synchronized diurnal culture 21h (CC-2895)
Synchronized diurnal culture 22h (CC-2895)
Synchronized diurnal culture 23h (CC-2895)
Synchronized diurnal culture 24h (CC-2895)
Nitrogen deficient 0min (wt, 2173)
Nitrogen deficient 8min (wt, 2173)
Nitrogen deficient 18min (wt, 2173)
Nitrogen deficient 45min (wt, 2173)
Nitrogen deficient 60min (wt, 2173)
Nitrogen minus 0h (sta_6)
Nitrogen minus 0.5h (sta_6)
Nitrogen minus 2h (sta_6)
Nitrogen minus 4h (sta_6)
Nitrogen minus 8h (sta_6)
Nitrogen minus 12h (sta_6)
Nitrogen minus 24h (sta_6)
Nitrogen minus 48h (sta_6)
Nitrogen starvation 0h (4A+, CC-4051)
Nitrogen starvation 0.5h (4A+, CC-4051)
Nitrogen starvation 10min (4A+, CC-4051)
Nitrogen starvation 1h (4A+, CC-4051)
Nitrogen starvation 2h (4A+, CC-4051)
Nitrogen starvation 6h (4A+, CC-4051)
Nitrogen starvation 8h (4A+, CC-4051)
Nitrogen starvation 24h (4A+, CC-4051)
Nitrogen starvation 48h (4A+, CC-4051)
Sulfur starvation 0h (4A+, CC-4051)
Sulfur starvation 0.5h (4A+, CC-4051)
Sulfur starvation 10min (4A+, CC-4051)
Sulfur starvation 1h (4A+, CC-4051)
Sulfur starvation 2h (4A+, CC-4051)
Sulfur starvation 6h (4A+, CC-4051)
Sulfur starvation 8h (4A+, CC-4051)
Sulfur starvation 24h (4A+, CC-4051)
Sulfur starvation 48h (4A+, CC-4051)
Copper deficient (wt, 2173)
Copper sufficient (wt, 2173)
Iron deprivation 0h (CC-4532)
Iron deprivation 0.5h (CC-4532)
Iron deprivation 1h (CC-4532)
Iron deprivation 2h (CC-4532)
Iron deprivation 4h (CC-4532)
Iron deprivation 8h (CC-4532)
Iron deprivation 12h (CC-4532)
Iron deprivation 24h (CC-4532)
Iron deprivation 48h (CC-4532)
Iron replete (wt, 2173)
Iron-deficient (wt, 2173)
Iron-limited (wt, 2173)
Zink minus (CC-4532)
Zink replete - early (CC-4532)
Zink replete - late (CC-4532)
Zink resupply 1.5h (CC-4532)
Zink resupply 3h (CC-4532)
Zink resupply 4.5h (CC-4532)
Zink resupply 12h (CC-4532)
Zink resupply 24h (CC-4532)
Vitamin B12 and thiamine 0h (A31)
Vitamin B12 and thiamine 0h (DHC16)
Vitamin B12 and thiamine 12h (A31)
Vitamin B12 and thiamine 12h (DHC16)
Vitamin B12 and thiamine 48h (A31)
Vitamin B12 and thiamine 48h (DHC16)
Hydrogen peroxide 0.5h (wt, 2173)
Hydrogen peroxide 0h (wt, 2173)
Hydrogen peroxide 1h (wt, 2173)
Rapamycin 0h (A31)
Rapamycin 0h (DHC16)
Rapamycin 2h (A31)
Rapamycin 8h (A31)
Rapamycin 12h (A31)
Rapamycin 12h (DHC16)
Rapamycin 48h (A31)
Rapamycin 48h (DHC16)
UV-B 1h (wt, CC-125)
BV IXa 0.1mM (4A+, CC-4051)
BV IXa 0.1mM (hmox1 mutant)
BV IXa 0mM (4A+, CC-4051)
BV IXa 0mM (hmox1 mutant)
-1.21 -2.9 -4.29 -3.09 -2.46 -1.57 -0.78 0.23 0.57 1.15 0.69 0.28 0.22 0.26 0.49 0.02 0.09 -0.21 -0.18 -0.31 -0.27 0.66 0.46 0.43 0.94 0.83 0.93 0.44 -2.42 -2.88 -4.34 -2.77 -2.0 -0.06 0.34 1.36 1.11 1.89 1.92 1.39 1.24 0.32 0.54 1.06 1.38 0.91 2.1 1.88 0.67 0.76 0.96 0.76 1.13 0.38 0.4 1.82 2.18 0.81 0.67 -0.09 -0.64 -4.15 -3.34 -4.05 -3.52 -3.76 -3.48 -2.8 -2.07 -1.84 -0.05 0.09 -0.93 -5.27 -4.29 -3.95 -4.12 -4.34 -5.39 -3.98 -4.18 -1.63 -3.05 -2.02 -2.94 -2.86 -3.8 -2.03 -1.51 -2.12 -1.63 -3.05 -1.91 -2.1 -2.02 -2.94 -2.86 -3.8 -3.47 -0.28 -0.03 -0.44 -0.44
0.59 0.04 -0.11 -0.48 -0.79 -0.52 -0.42 -0.23 -0.69 -0.12 0.07 -0.33 -0.16 -0.25 0.0 -0.41 -0.3 -0.24 -0.28 0.02 -0.1 0.67 0.83 0.82 1.14 1.25 1.61 1.28 -0.08 0.2 0.3 0.83 0.66 -0.69 -0.4 0.73 0.7 0.99 1.15 1.09 0.9 -0.88 0.17 -1.67 0.8 0.59 1.06 1.22 0.84 0.77 0.01 0.05 0.08 -0.12 0.32 0.69 1.13 1.15 0.72 0.39 -0.28 -0.75 -1.47 -1.22 -1.4 -1.88 -1.41 -1.38 -1.01 -0.19 0.58 0.57 0.28 -1.73 -2.48 -2.17 -1.0 -1.71 -1.98 -2.02 -2.27 -1.43 -2.49 -1.19 -2.0 -2.19 -1.12 0.2 -0.43 -0.44 -1.43 -2.49 -1.18 -1.27 -1.19 -2.0 -2.19 -1.12 -0.16 -0.55 -0.47 -0.65 -0.24
-0.14 -0.72 -1.5 -1.26 -1.38 -0.74 -0.65 -0.72 -1.05 -0.33 -0.39 -0.62 -0.43 -0.74 -0.34 -0.6 -0.46 -0.54 -0.44 -0.33 0.01 0.85 0.97 0.84 1.18 1.19 1.41 1.08 -0.55 -1.07 -1.51 -0.95 -0.73 0.77 1.28 1.38 1.16 1.64 1.8 1.83 1.52 -0.94 0.33 0.35 0.04 -0.65 1.2 1.04 0.77 1.58 0.44 0.15 -0.04 -0.27 -0.29 0.85 1.11 0.67 0.99 0.62 0.01 -1.85 -1.78 -1.73 -1.83 -1.97 -1.78 -1.9 -1.09 -0.6 0.42 0.24 -0.31 -2.24 -2.76 -2.23 -1.26 -2.34 -2.77 -2.52 -2.44 -0.67 -1.1 -0.62 -0.97 -2.22 -0.95 -0.61 -0.76 -1.18 -0.67 -1.1 -0.84 -0.82 -0.62 -0.97 -2.22 -0.95 0.03 -0.51 -0.28 -0.84 -0.61
-0.35 -1.73 -1.82 -1.69 -2.43 -2.07 -2.34 -2.42 -2.44 -1.32 -1.04 -1.06 -0.87 -1.07 -0.1 -0.91 -0.66 -0.44 -0.46 -0.23 -0.04 0.84 0.65 0.73 1.08 0.94 0.83 0.68 -1.24 -1.93 -1.53 -0.27 0.25 1.06 1.46 1.97 1.81 2.19 2.25 2.1 1.76 -0.82 0.3 -0.91 0.69 0.42 0.71 1.26 0.46 0.19 0.4 -0.02 0.09 -0.25 0.64 1.62 1.9 2.16 2.11 -0.55 -0.94 -3.12 -2.87 -3.25 -2.69 -2.83 -2.73 -3.14 -1.99 -1.17 -0.0 -0.11 -0.45 -3.32 -3.27 -2.65 -2.71 -3.4 -3.78 -2.89 -3.09 -1.1 -1.54 -1.22 -1.86 -2.72 -1.39 -1.88 -1.63 -2.19 -1.1 -1.54 -2.02 -2.04 -1.22 -1.86 -2.72 -1.39 -1.55 -0.37 -1.04 -0.45 -1.09
2.09 1.23 0.6 -0.49 -1.08 -0.5 -0.53 0.07 0.79 1.64 1.56 1.69 1.21 0.1 0.29 0.64 0.98 1.02 1.01 0.98 1.38 1.83 1.92 1.62 1.65 1.46 1.24 1.45 -1.84 -3.33 -5.1 -6.3 -6.08 -1.94 0.67 2.4 2.31 1.38 1.48 2.08 2.51 -6.52 -3.93 -4.65 -5.39 -4.6 -6.27 -5.11 -5.38 -2.41 -1.13 -0.21 -1.6 -0.82 -2.04 -3.79 -3.93 -3.69 -2.95 -1.55 -1.49 -2.46 -3.46 -1.86 -1.8 -3.02 -5.74 -6.77 -3.69 -6.57 -1.42 -1.09 -1.78 -3.97 -2.55 -4.29 -1.32 -1.61 -1.89 -2.61 -2.72 -4.49 -6.28 -0.14 -3.19 -2.42 -4.58 -0.72 -1.3 -1.72 -4.49 -6.28 -1.53 0.83 -0.14 -3.19 -2.42 -4.58 -2.62 -5.0 -3.33 -3.85 -3.91
-0.2 -0.82 -0.88 -1.06 -1.2 -1.09 -0.87 -0.59 -0.93 -0.5 -0.73 -0.61 -0.41 0.26 0.29 0.45 0.55 0.63 0.42 0.66 0.89 1.17 1.22 1.18 1.25 1.11 1.25 1.77 -0.76 -0.92 -1.24 -1.09 -0.39 -0.68 0.29 0.73 0.73 1.31 1.49 1.34 1.1 -0.19 0.43 0.45 0.53 0.17 1.23 0.95 0.95 1.11 -0.34 -1.03 -0.22 -0.66 -0.34 0.79 0.92 0.87 1.06 -0.18 -0.31 -0.7 -0.97 -1.2 -1.1 -1.23 -1.24 -2.36 -0.59 -0.52 -0.54 -0.47 -0.86 -2.29 -2.24 -1.62 -1.9 -2.63 -2.59 -1.92 -1.82 -0.06 -1.12 -0.88 -1.42 -1.38 -0.91 -0.63 -0.89 -0.99 -0.06 -1.12 -0.92 -1.16 -0.88 -1.42 -1.38 -0.91 -1.19 -0.27 -0.23 -0.26 -0.39
0.54 -0.47 0.55 0.26 0.18 0.47 0.58 0.8 0.63 0.64 0.46 0.19 -0.12 -0.5 -0.53 -0.66 -0.23 -0.47 -0.84 0.08 -0.18 0.5 1.08 0.96 1.26 1.49 1.64 1.65 -1.0 -1.23 -1.68 -0.56 0.22 -0.21 0.74 0.78 0.81 1.32 1.42 1.43 1.28 -0.23 0.67 -0.28 0.93 0.6 0.64 0.77 0.42 0.28 0.09 -0.14 0.06 -0.18 -0.31 0.42 0.78 0.41 0.69 -0.11 -0.63 -1.5 -1.64 -1.21 -1.28 -1.88 -1.23 -2.03 -1.73 -0.29 -0.55 -0.8 -1.69 -4.21 -3.06 -2.25 -2.7 -3.28 -3.07 -2.5 -2.52 -0.81 -1.44 -0.43 -1.38 -1.71 -0.69 -1.32 -0.92 -0.99 -0.81 -1.44 -0.45 -0.16 -0.43 -1.38 -1.71 -0.69 -0.77 -0.55 -0.66 -0.41 -0.51
-2.17 -1.06 -1.56 -1.51 -1.36 -1.63 -1.14 -0.67 -0.72 -0.36 -0.72 -0.75 -0.9 -0.16 0.04 -0.29 -0.04 0.08 0.01 -0.19 0.3 0.81 0.81 0.79 0.78 0.81 0.52 0.39 -0.97 -0.52 -1.58 -0.14 0.05 -0.15 0.82 1.3 1.16 1.35 1.56 1.19 1.09 0.18 0.63 -0.06 0.92 0.63 1.28 1.32 1.29 1.22 0.35 0.19 0.14 0.24 0.38 0.66 0.86 1.09 1.13 -0.18 -0.51 -1.59 -1.53 -1.4 -1.24 -0.96 -0.68 -1.03 0.1 0.98 0.01 0.31 0.02 -1.74 -1.75 -1.11 -1.41 -1.63 -1.91 -1.3 -1.32 -0.11 -0.83 -0.92 -1.04 -1.36 -0.68 -0.71 -0.61 -1.03 -0.11 -0.83 -1.08 -1.04 -0.92 -1.04 -1.36 -0.68 -0.83 -0.77 -1.09 -0.88 -1.37
-4.2 -4.83 -6.91 -3.05 -1.94 -1.65 -0.8 -0.61 -0.79 -0.93 -0.93 -1.72 -0.96 0.21 0.48 0.39 0.51 0.21 0.3 0.37 0.5 1.08 0.69 0.92 1.43 1.26 1.46 0.93 -1.21 -0.65 -2.82 -0.82 -0.22 1.47 0.55 0.81 0.97 1.8 1.95 1.91 1.87 0.6 -0.06 1.06 0.73 0.77 2.04 1.63 1.58 1.85 -0.49 -1.74 0.41 -1.03 -0.08 1.16 1.27 0.15 0.74 -0.56 -0.28 -2.82 -4.18 -3.52 -3.48 -2.99 -1.85 -1.95 -1.21 -1.26 -0.13 0.16 -0.64 -3.92 -3.58 -2.84 -4.02 -4.87 -5.3 -3.14 -3.34 -0.86 -1.98 -1.36 -1.16 -1.57 -2.64 -0.79 -1.03 -1.15 -0.86 -1.98 -1.55 -2.16 -1.36 -1.16 -1.57 -2.64 -2.03 -1.69 -1.77 -1.63 -1.7
0.89 0.46 -0.28 -0.25 0.01 0.4 0.39 0.25 0.04 0.26 -0.15 -0.06 -0.09 -1.06 -0.59 -0.4 -0.54 -0.3 -0.71 -0.85 -0.91 -1.0 -1.2 -1.22 -1.5 -1.77 -1.49 -1.24 0.51 -0.19 0.79 0.65 0.31 -0.44 1.49 1.37 1.06 0.87 0.88 -0.02 -0.08 -0.42 2.15 1.53 1.53 0.98 1.6 1.39 0.07 -0.68 -0.04 1.13 0.47 1.11 0.6 0.96 0.91 0.5 0.81 -1.14 -1.49 -0.76 -0.74 -1.42 -1.35 -1.39 -0.65 -0.75 -0.83 -3.24 -1.98 -2.18 -2.27 -1.52 -1.03 -1.1 -1.63 -1.91 -1.55 -1.54 -0.71 -3.29 -4.77 0.53 -0.07 -1.57 -0.73 -0.61 -0.67 -0.85 -3.29 -4.77 -1.27 -0.87 0.53 -0.07 -1.57 -0.73 -1.16 0.42 0.06 0.42 0.39
0.68 0.3 -0.29 -0.03 0.15 0.54 0.54 0.3 0.2 0.37 -0.04 -0.16 -0.16 -1.09 -0.85 -0.43 -0.73 -0.57 -0.76 -1.03 -0.92 -1.1 -1.3 -1.43 -1.53 -1.84 -1.88 -1.1 0.93 0.16 1.03 0.88 0.64 -0.26 1.67 1.59 1.13 0.85 0.91 -0.04 0.03 -0.12 1.85 1.23 1.17 0.64 1.2 0.93 0.03 -0.76 -0.92 0.24 -0.36 0.22 0.17 0.44 0.49 0.14 0.36 -0.94 -1.38 -0.3 0.05 -0.63 -0.92 -0.88 -0.32 -0.17 -0.21 -2.83 -2.05 -1.83 -2.06 -0.67 -1.03 -1.12 -1.15 -1.36 -1.29 -1.43 -0.61 -3.04 -3.87 1.0 0.32 -1.14 -0.16 0.31 0.08 0.01 -3.04 -3.87 -0.83 -0.67 1.0 0.32 -1.14 -0.16 -1.2 0.24 -0.09 0.33 0.23
- - - - - - - - - - - - - - - - - - - - - - - - - - - - -0.71 -0.25 0.25 1.49 1.8 0.92 2.01 1.98 1.43 1.63 1.59 1.47 1.42 -0.03 1.84 0.42 1.7 1.65 1.44 1.53 1.59 1.74 -0.24 -0.69 -0.45 -0.35 0.35 0.73 0.97 2.09 1.83 -0.22 -0.61 -0.05 -0.58 -0.93 -1.33 -1.41 -0.58 -0.78 -0.46 -0.22 -0.0 0.1 -0.01 -1.26 -2.41 -1.62 -2.12 -2.09 -2.12 -1.69 -1.72 -0.26 -1.07 -0.01 -0.61 -0.97 0.11 0.23 -0.62 0.83 -0.26 -1.07 0.04 0.28 -0.01 -0.61 -0.97 0.11 -1.68 -1.09 -0.71 -1.08 -0.68
-1.1 -0.78 -1.13 -0.98 -1.12 -0.6 -0.51 -0.13 -0.54 -0.15 -0.58 -0.83 -0.97 -1.58 -1.44 -1.4 -1.06 -0.95 -0.86 -0.66 -0.14 0.85 0.91 0.83 1.44 1.41 1.11 0.81 -0.02 0.83 0.09 0.1 0.23 1.51 2.1 0.98 0.62 1.13 1.29 1.41 1.29 -0.28 0.82 0.33 0.39 -0.09 1.02 1.0 0.93 1.11 0.21 0.33 0.51 -0.12 0.07 0.93 1.05 0.54 0.56 0.47 0.07 -1.3 -1.52 -2.02 -1.59 -1.9 -1.39 -1.37 -1.72 -1.19 0.84 0.85 0.15 -2.78 -2.57 -2.26 -1.84 -2.32 -2.55 -2.13 -2.43 -0.74 -1.79 -1.16 -1.43 -2.44 -1.46 -0.66 -0.55 -0.96 -0.74 -1.79 -1.36 -1.63 -1.16 -1.43 -2.44 -1.46 -0.16 -0.13 -1.22 0.14 -1.16
0.44 -0.29 -1.46 -1.69 -1.9 -1.67 -1.72 -1.72 -1.75 -1.41 -1.78 -1.89 -2.01 -1.3 -0.63 -0.52 -0.25 -0.19 -0.27 -0.16 0.13 0.72 0.7 0.21 0.62 0.35 0.75 0.96 -0.36 0.11 0.37 0.55 0.71 0.45 1.69 1.12 1.48 2.04 2.09 1.85 1.65 -0.67 1.24 1.67 0.22 0.37 1.78 1.07 0.69 0.42 0.1 0.45 1.16 -0.35 0.13 1.3 1.52 1.97 2.12 -0.44 -1.0 -1.43 -2.48 -2.66 -2.11 -2.35 -2.23 -2.85 -1.56 -1.61 -0.94 -0.93 -1.17 -4.16 -3.14 -2.91 -2.8 -3.26 -3.65 -3.15 -3.2 -2.25 -5.61 -2.38 -3.64 -3.69 -2.54 0.08 -0.44 -0.6 -2.25 -5.61 -2.82 -2.53 -2.38 -3.64 -3.69 -2.54 -1.97 -0.83 -1.3 -0.98 -1.15
-0.59 -1.92 -1.95 -2.73 -1.7 -1.47 -1.25 -0.99 -0.61 0.21 0.52 0.43 0.43 0.48 0.93 0.46 0.56 0.35 0.73 0.82 0.7 1.2 1.28 1.32 1.57 1.91 2.13 1.46 -2.7 -4.0 - -2.22 - -2.08 -0.43 1.29 1.3 2.07 2.27 2.23 2.05 -1.42 -2.04 -2.51 -1.71 -0.14 0.17 1.48 2.51 2.47 -1.16 -1.36 -1.91 -1.23 -1.62 -0.48 0.17 0.19 0.6 0.07 -1.12 -3.57 -3.94 -4.08 -3.73 -3.9 -3.86 -3.02 -2.06 -0.52 -1.34 -1.34 -2.19 -4.68 -3.8 -3.27 -3.68 -4.44 -4.59 -4.21 -3.39 -0.49 -1.16 -0.91 -0.61 -2.21 -2.46 -1.77 -1.94 -2.58 -0.49 -1.16 -4.52 -5.3 -0.91 -0.61 -2.21 -2.46 -0.78 -1.22 -1.48 -1.42 -1.56
-1.8 -1.97 -2.76 -2.52 -2.82 -1.77 -1.7 -1.06 -1.53 -1.5 -1.48 -1.38 -1.64 -1.32 -0.88 -1.26 -1.2 -1.33 -1.45 -1.13 -0.76 0.06 0.17 0.23 0.72 0.67 0.66 0.34 -1.23 -0.21 -1.59 0.18 1.05 0.21 0.78 1.32 1.38 2.31 2.43 2.27 2.22 -0.69 -0.17 0.02 0.55 0.94 2.32 1.98 1.71 1.66 -0.06 -1.88 -0.02 -1.06 -0.64 1.42 1.66 0.05 0.76 1.64 1.27 -1.92 -2.65 -2.88 -2.45 -2.51 -2.12 -2.62 -2.34 -2.28 0.8 0.57 -0.21 -4.72 -3.69 -3.47 -4.07 -4.49 -4.94 -3.88 -3.85 -1.21 -2.99 -1.48 -2.2 -3.16 -2.98 -0.84 -1.4 -0.94 -1.21 -2.99 -1.55 -1.95 -1.48 -2.2 -3.16 -2.98 -1.93 0.19 -1.12 0.39 -0.98
-2.44 -1.59 -3.5 -2.85 -2.79 -2.04 -1.57 -1.12 -1.7 -0.71 -1.37 -1.69 -2.0 -1.51 -1.64 -2.5 -1.16 -1.51 -2.05 -1.27 -1.06 -0.29 0.18 0.0 0.55 0.49 0.4 0.22 -1.29 -0.17 -0.79 0.61 1.46 0.2 0.52 1.12 1.37 2.27 2.38 2.03 2.44 -1.39 -1.1 -0.72 -0.1 0.2 1.69 1.33 1.3 1.06 -0.68 -2.42 -0.8 -1.16 -1.62 0.54 0.95 -1.29 0.18 1.85 1.42 0.28 -0.39 -0.11 -0.46 -1.09 -0.43 -1.07 -0.35 -0.77 0.7 0.06 0.29 -2.01 -2.34 -2.33 -2.66 -2.85 -2.92 -2.53 -2.27 -0.69 -0.92 0.37 -0.37 -2.32 -0.54 -0.39 -1.41 -0.49 -0.69 -0.92 -0.4 -0.66 0.37 -0.37 -2.32 -0.54 -0.55 0.22 -0.9 0.57 -0.92
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Details

Dark gray cells indicate values where the raw expression is zero (cannot be log-transformed). Blue cells indicate samples where the expression of the gene is below average and red cells indicate the gene is expressed above average in the sample. White cells are average.