AT4G09140 (MLH1, ATMLH1)

Aliases : MLH1, ATMLH1

Description : MUTL-homologue 1

Gene families : OG0005285 (Archaeplastida) Phylogenetic Tree(s): OG0005285_tree ,
OG_05_0007792 (LandPlants) Phylogenetic Tree(s): OG_05_0007792_tree ,
OG_06_0008410 (SeedPlants) Phylogenetic Tree(s): OG_06_0008410_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AT4G09140
Cluster	HCCA: Cluster_91

Target	Alias	Description	ECC score	Gene Family Method	Actions
MA_10425989g0010	No alias	DNA mismatch repair protein MLH1 OS=Arabidopsis thaliana...	0.02	Archaeplastida
Solyc04g045660.4.1	No alias	component MLH1 of MLH1-PMS1 heterodimer	0.04	Archaeplastida

Type	GO Term	Name	Evidence	Source
BP	GO:0000278	mitotic cell cycle	RCA	Interproscan
BP	GO:0000724	double-strand break repair via homologous recombination	RCA	Interproscan
BP	GO:0000725	recombinational repair	None	Extended
CC	GO:0000785	chromatin	None	Extended
CC	GO:0000790	nuclear chromatin	IDA	Interproscan
CC	GO:0000795	synaptonemal complex	IBA	Interproscan
BP	GO:0001101	response to acid chemical	None	Extended
BP	GO:0003006	developmental process involved in reproduction	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	None	Extended
MF	GO:0003690	double-stranded DNA binding	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0005488	binding	None	Extended
MF	GO:0005515	protein binding	None	Extended
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005634	nucleus	ISM	Interproscan
CC	GO:0005712	chiasma	IBA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006260	DNA replication	None	Extended
BP	GO:0006261	DNA-dependent DNA replication	RCA	Interproscan
BP	GO:0006275	regulation of DNA replication	RCA	Interproscan
BP	GO:0006281	DNA repair	None	Extended
BP	GO:0006298	mismatch repair	ISS	Interproscan
BP	GO:0006298	mismatch repair	IBA	Interproscan
BP	GO:0006302	double-strand break repair	RCA	Interproscan
BP	GO:0006304	DNA modification	None	Extended
BP	GO:0006305	DNA alkylation	None	Extended
BP	GO:0006306	DNA methylation	RCA	Interproscan
BP	GO:0006310	DNA recombination	None	Extended
BP	GO:0006312	mitotic recombination	IMP	Interproscan
BP	GO:0006312	mitotic recombination	RCA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006950	response to stress	None	Extended
BP	GO:0006974	cellular response to DNA damage stimulus	None	Extended
BP	GO:0006996	organelle organization	None	Extended
BP	GO:0007049	cell cycle	None	Extended
BP	GO:0007059	chromosome segregation	None	Extended
BP	GO:0007062	sister chromatid cohesion	RCA	Interproscan
BP	GO:0007129	synapsis	RCA	Interproscan
BP	GO:0007131	reciprocal meiotic recombination	IBA	Interproscan
BP	GO:0007131	reciprocal meiotic recombination	RCA	Interproscan
BP	GO:0007275	multicellular organism development	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009059	macromolecule biosynthetic process	None	Extended
BP	GO:0009555	pollen development	IMP	Interproscan
BP	GO:0009555	pollen development	RCA	Interproscan
BP	GO:0009560	embryo sac egg cell differentiation	RCA	Interproscan
BP	GO:0009719	response to endogenous stimulus	None	Extended
BP	GO:0009725	response to hormone	None	Extended
BP	GO:0009737	response to abscisic acid	RCA	Interproscan
BP	GO:0009790	embryo development	None	Extended
BP	GO:0009791	post-embryonic development	None	Extended
BP	GO:0009793	embryo development ending in seed dormancy	RCA	Interproscan
BP	GO:0009845	seed germination	IMP	Interproscan
BP	GO:0009845	seed germination	RCA	Interproscan
BP	GO:0009889	regulation of biosynthetic process	None	Extended
BP	GO:0009892	negative regulation of metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0010033	response to organic substance	None	Extended
BP	GO:0010154	fruit development	IMP	Interproscan
BP	GO:0010162	seed dormancy process	RCA	Interproscan
BP	GO:0010468	regulation of gene expression	None	Extended
BP	GO:0010556	regulation of macromolecule biosynthetic process	None	Extended
BP	GO:0010564	regulation of cell cycle process	RCA	Interproscan
BP	GO:0010605	negative regulation of macromolecule metabolic process	None	Extended
BP	GO:0010629	negative regulation of gene expression	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
BP	GO:0016444	somatic cell DNA recombination	RCA	Interproscan
BP	GO:0016458	gene silencing	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016887	ATPase activity	IBA	Interproscan
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	None	Extended
BP	GO:0019222	regulation of metabolic process	None	Extended
BP	GO:0022402	cell cycle process	None	Extended
BP	GO:0022412	cellular process involved in reproduction in multicellular organism	None	Extended
BP	GO:0022414	reproductive process	None	Extended
BP	GO:0022611	dormancy process	None	Extended
BP	GO:0030154	cell differentiation	None	Extended
MF	GO:0030674	protein binding, bridging	ISS	Interproscan
MF	GO:0030983	mismatched DNA binding	IBA	Interproscan
BP	GO:0031047	gene silencing by RNA	RCA	Interproscan
BP	GO:0031323	regulation of cellular metabolic process	None	Extended
BP	GO:0031326	regulation of cellular biosynthetic process	None	Extended
BP	GO:0032259	methylation	None	Extended
CC	GO:0032300	mismatch repair complex	None	Extended
CC	GO:0032389	MutLalpha complex	IBA	Interproscan
CC	GO:0032390	MutLbeta complex	IBA	Interproscan
BP	GO:0032501	multicellular organismal process	None	Extended
BP	GO:0032502	developmental process	None	Extended
CC	GO:0032991	protein-containing complex	None	Extended
BP	GO:0033554	cellular response to stress	None	Extended
BP	GO:0033993	response to lipid	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0034645	cellular macromolecule biosynthetic process	None	Extended
BP	GO:0035825	homologous recombination	None	Extended
BP	GO:0042138	meiotic DNA double-strand break formation	RCA	Interproscan
BP	GO:0042221	response to chemical	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
CC	GO:0043226	organelle	None	Extended
CC	GO:0043227	membrane-bounded organelle	None	Extended
CC	GO:0043229	intracellular organelle	None	Extended
CC	GO:0043231	intracellular membrane-bounded organelle	None	Extended
BP	GO:0043412	macromolecule modification	None	Extended
BP	GO:0043414	macromolecule methylation	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
CC	GO:0044422	organelle part	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044427	chromosomal part	None	Extended
CC	GO:0044428	nuclear part	None	Extended
CC	GO:0044446	intracellular organelle part	None	Extended
CC	GO:0044454	nuclear chromosome part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0044728	DNA methylation or demethylation	None	Extended
BP	GO:0045132	meiotic chromosome segregation	RCA	Interproscan
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0048229	gametophyte development	None	Extended
BP	GO:0048316	seed development	IMP	Interproscan
BP	GO:0048366	leaf development	RCA	Interproscan
BP	GO:0048519	negative regulation of biological process	None	Extended
BP	GO:0048608	reproductive structure development	None	Extended
BP	GO:0048609	multicellular organismal reproductive process	None	Extended
BP	GO:0048825	cotyledon development	RCA	Interproscan
BP	GO:0048827	phyllome development	None	Extended
BP	GO:0048856	anatomical structure development	None	Extended
BP	GO:0048869	cellular developmental process	None	Extended
BP	GO:0050789	regulation of biological process	None	Extended
BP	GO:0050794	regulation of cellular process	None	Extended
BP	GO:0050896	response to stimulus	None	Extended
BP	GO:0051052	regulation of DNA metabolic process	None	Extended
BP	GO:0051171	regulation of nitrogen compound metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
BP	GO:0051716	cellular response to stimulus	None	Extended
BP	GO:0051726	regulation of cell cycle	RCA	Interproscan
MF	GO:0060090	molecular adaptor activity	None	Extended
BP	GO:0060255	regulation of macromolecule metabolic process	None	Extended
BP	GO:0061982	meiosis I cell cycle process	None	Extended
BP	GO:0065007	biological regulation	None	Extended
BP	GO:0070192	chromosome organization involved in meiotic cell cycle	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0080090	regulation of primary metabolic process	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
BP	GO:0090305	nucleic acid phosphodiester bond hydrolysis	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
BP	GO:0097305	response to alcohol	None	Extended
BP	GO:0098813	nuclear chromosome segregation	None	Extended
CC	GO:0099086	synaptonemal structure	None	Extended
BP	GO:0099402	plant organ development	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended
BP	GO:1901700	response to oxygen-containing compound	None	Extended
BP	GO:1903046	meiotic cell cycle process	None	Extended
CC	GO:1990391	DNA repair complex	None	Extended
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000175	3'-5'-exoribonuclease activity	IEP	Neighborhood
BP	GO:0000226	microtubule cytoskeleton organization	IEP	Neighborhood
MF	GO:0000339	RNA cap binding	IEP	Neighborhood
BP	GO:0000375	RNA splicing, via transesterification reactions	IEP	Neighborhood
BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	IEP	Neighborhood
BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	IEP	Neighborhood
BP	GO:0000398	mRNA splicing, via spliceosome	IEP	Neighborhood
BP	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis	IEP	Neighborhood
BP	GO:0000914	phragmoplast assembly	IEP	Neighborhood
BP	GO:0000959	mitochondrial RNA metabolic process	IEP	Neighborhood
MF	GO:0003723	RNA binding	IEP	Neighborhood
MF	GO:0003747	translation release factor activity	IEP	Neighborhood
MF	GO:0004518	nuclease activity	IEP	Neighborhood
MF	GO:0004527	exonuclease activity	IEP	Neighborhood
MF	GO:0004532	exoribonuclease activity	IEP	Neighborhood
MF	GO:0004815	aspartate-tRNA ligase activity	IEP	Neighborhood
CC	GO:0005667	transcription factor complex	IEP	Neighborhood
CC	GO:0005675	transcription factor TFIIH holo complex	IEP	Neighborhood
CC	GO:0005730	nucleolus	IEP	Neighborhood
BP	GO:0006289	nucleotide-excision repair	IEP	Neighborhood
BP	GO:0006325	chromatin organization	IEP	Neighborhood
BP	GO:0006351	transcription, DNA-templated	IEP	Neighborhood
BP	GO:0006357	regulation of transcription by RNA polymerase II	IEP	Neighborhood
BP	GO:0006366	transcription by RNA polymerase II	IEP	Neighborhood
BP	GO:0006396	RNA processing	IEP	Neighborhood
BP	GO:0006397	mRNA processing	IEP	Neighborhood
BP	GO:0006415	translational termination	IEP	Neighborhood
BP	GO:0006422	aspartyl-tRNA aminoacylation	IEP	Neighborhood
BP	GO:0006464	cellular protein modification process	IEP	Neighborhood
BP	GO:0006476	protein deacetylation	IEP	Neighborhood
BP	GO:0006479	protein methylation	IEP	Neighborhood
BP	GO:0006505	GPI anchor metabolic process	IEP	Neighborhood
BP	GO:0006506	GPI anchor biosynthetic process	IEP	Neighborhood
BP	GO:0007017	microtubule-based process	IEP	Neighborhood
MF	GO:0008079	translation termination factor activity	IEP	Neighborhood
MF	GO:0008131	primary amine oxidase activity	IEP	Neighborhood
BP	GO:0008213	protein alkylation	IEP	Neighborhood
BP	GO:0008380	RNA splicing	IEP	Neighborhood
MF	GO:0008408	3'-5' exonuclease activity	IEP	Neighborhood
BP	GO:0009640	photomorphogenesis	IEP	Neighborhood
BP	GO:0009756	carbohydrate mediated signaling	IEP	Neighborhood
BP	GO:0009909	regulation of flower development	IEP	Neighborhood
BP	GO:0009911	positive regulation of flower development	IEP	Neighborhood
BP	GO:0009933	meristem structural organization	IEP	Neighborhood
BP	GO:0010093	specification of floral organ identity	IEP	Neighborhood
BP	GO:0010182	sugar mediated signaling pathway	IEP	Neighborhood
BP	GO:0010228	vegetative to reproductive phase transition of meristem	IEP	Neighborhood
BP	GO:0010229	inflorescence development	IEP	Neighborhood
BP	GO:0016070	RNA metabolic process	IEP	Neighborhood
BP	GO:0016071	mRNA metabolic process	IEP	Neighborhood
BP	GO:0016567	protein ubiquitination	IEP	Neighborhood
BP	GO:0016569	covalent chromatin modification	IEP	Neighborhood
BP	GO:0016570	histone modification	IEP	Neighborhood
BP	GO:0016571	histone methylation	IEP	Neighborhood
BP	GO:0016575	histone deacetylation	IEP	Neighborhood
MF	GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors	IEP	Neighborhood
MF	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor	IEP	Neighborhood
MF	GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	IEP	Neighborhood
MF	GO:0016896	exoribonuclease activity, producing 5'-phosphomonoesters	IEP	Neighborhood
BP	GO:0018022	peptidyl-lysine methylation	IEP	Neighborhood
BP	GO:0018130	heterocycle biosynthetic process	IEP	Neighborhood
BP	GO:0019538	protein metabolic process	IEP	Neighborhood
BP	GO:0019915	lipid storage	IEP	Neighborhood
BP	GO:0022411	cellular component disassembly	IEP	Neighborhood
BP	GO:0031053	primary miRNA processing	IEP	Neighborhood
BP	GO:0031109	microtubule polymerization or depolymerization	IEP	Neighborhood
BP	GO:0032446	protein modification by small protein conjugation	IEP	Neighborhood
BP	GO:0032506	cytokinetic process	IEP	Neighborhood
BP	GO:0032774	RNA biosynthetic process	IEP	Neighborhood
CC	GO:0032806	carboxy-terminal domain protein kinase complex	IEP	Neighborhood
BP	GO:0032984	protein-containing complex disassembly	IEP	Neighborhood
BP	GO:0034470	ncRNA processing	IEP	Neighborhood
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Neighborhood
BP	GO:0034660	ncRNA metabolic process	IEP	Neighborhood
BP	GO:0034968	histone lysine methylation	IEP	Neighborhood
BP	GO:0035601	protein deacylation	IEP	Neighborhood
BP	GO:0036211	protein modification process	IEP	Neighborhood
BP	GO:0043624	cellular protein complex disassembly	IEP	Neighborhood
BP	GO:0044267	cellular protein metabolic process	IEP	Neighborhood
CC	GO:0044798	nuclear transcription factor complex	IEP	Neighborhood
BP	GO:0046785	microtubule polymerization	IEP	Neighborhood
BP	GO:0048532	anatomical structure arrangement	IEP	Neighborhood
BP	GO:0048571	long-day photoperiodism	IEP	Neighborhood
BP	GO:0048574	long-day photoperiodism, flowering	IEP	Neighborhood
BP	GO:0048580	regulation of post-embryonic development	IEP	Neighborhood
BP	GO:0048768	root hair cell tip growth	IEP	Neighborhood
BP	GO:0048831	regulation of shoot system development	IEP	Neighborhood
BP	GO:0050793	regulation of developmental process	IEP	Neighborhood
BP	GO:0050826	response to freezing	IEP	Neighborhood
BP	GO:0051235	maintenance of location	IEP	Neighborhood
BP	GO:0051239	regulation of multicellular organismal process	IEP	Neighborhood
BP	GO:0051258	protein polymerization	IEP	Neighborhood
BP	GO:0051604	protein maturation	IEP	Neighborhood
CC	GO:0061695	transferase complex, transferring phosphorus-containing groups	IEP	Neighborhood
BP	GO:0070647	protein modification by small protein conjugation or removal	IEP	Neighborhood
BP	GO:0080156	mitochondrial mRNA modification	IEP	Neighborhood
CC	GO:0090575	RNA polymerase II transcription factor complex	IEP	Neighborhood
BP	GO:0090701	specification of plant organ identity	IEP	Neighborhood
BP	GO:0097659	nucleic acid-templated transcription	IEP	Neighborhood
BP	GO:0098732	macromolecule deacylation	IEP	Neighborhood
MF	GO:0140098	catalytic activity, acting on RNA	IEP	Neighborhood
BP	GO:1900864	mitochondrial RNA modification	IEP	Neighborhood
BP	GO:1902407	assembly of actomyosin apparatus involved in mitotic cytokinesis	IEP	Neighborhood
BP	GO:1902410	mitotic cytokinetic process	IEP	Neighborhood
CC	GO:1902494	catalytic complex	IEP	Neighborhood
CC	GO:1902554	serine/threonine protein kinase complex	IEP	Neighborhood
CC	GO:1902911	protein kinase complex	IEP	Neighborhood
BP	GO:1903047	mitotic cell cycle process	IEP	Neighborhood
CC	GO:1990234	transferase complex	IEP	Neighborhood
BP	GO:2000026	regulation of multicellular organismal development	IEP	Neighborhood
BP	GO:2000241	regulation of reproductive process	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR013507	DNA_mismatch_S5_2-like	237	356
IPR032189	Mlh1_C	454	737

External Links

No external refs found!

AT4G09140 (MLH1, ATMLH1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation