Smo172620

Description : Protein degradation.peptide tagging.Ubiquitin (UBQ)-anchor addition (ubiquitylation).UBQ-ligase E3 activities.Cullin-based ubiquitylation complexes.CUL4-DDB1 ubiquitination complexes.CUL4 scaffold component

Gene families : OG0001033 (Archaeplastida) Phylogenetic Tree(s): OG0001033_tree ,
OG_05_0004845 (LandPlants) Phylogenetic Tree(s): OG_05_0004845_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: Smo172620
Cluster	HCCA: Cluster_75

Target	Alias	Description	ECC score	Gene Family Method
AT1G26830	ATCUL3A, ATCUL3,...	cullin 3	0.02	Archaeplastida
Cpa\|evm.model.tig00000157.110	No alias	Cullin-4 OS=Arabidopsis thaliana	0.02	Archaeplastida
Cpa\|evm.model.tig00020563.190	No alias	Cullin-4 OS=Arabidopsis thaliana	0.02	Archaeplastida
Cre07.g324050	No alias	Protein degradation.peptide tagging.Ubiquitin...	0.02	Archaeplastida
Gb_08728	No alias	scaffold component CUL4 of CUL4-DDB1 ubiquitination...	0.02	Archaeplastida
LOC_Os03g57290.1	No alias	scaffold component CUL4 of CUL4-DDB1 ubiquitination...	0.02	Archaeplastida
MA_779048g0010	No alias	Cullin-4 OS=Arabidopsis thaliana (sp\|q8lgh4\|cul4_arath : 450.0)	0.02	Archaeplastida
Mp1g07340.1	No alias	scaffold component CUL4 of CUL4-DDB1 ubiquitination...	0.06	Archaeplastida
Mp4g12190.1	No alias	scaffold component CUL3 of CUL3-BTB E3 ligase complexes	0.02	Archaeplastida
Pp3c11_21000V3.1	No alias	cullin 3	0.06	Archaeplastida
Pp3c7_5730V3.1	No alias	cullin 3	0.02	Archaeplastida
Zm00001e005919_P001	No alias	scaffold component CUL4 of CUL4-DDB1 ubiquitination...	0.03	Archaeplastida

Type	GO Term	Name	Evidence	Source
BP	GO:0006508	proteolysis	None	Extended
BP	GO:0006511	ubiquitin-dependent protein catabolic process	IEA	Interproscan
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009056	catabolic process	None	Extended
BP	GO:0009057	macromolecule catabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0019538	protein metabolic process	None	Extended
BP	GO:0019941	modification-dependent protein catabolic process	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0043632	modification-dependent macromolecule catabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044248	cellular catabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0044265	cellular macromolecule catabolic process	None	Extended
BP	GO:0051603	proteolysis involved in cellular protein catabolic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901575	organic substance catabolic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Neighborhood
MF	GO:0003674	molecular_function	IEP	Neighborhood
MF	GO:0003676	nucleic acid binding	IEP	Neighborhood
MF	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity	IEP	Neighborhood
MF	GO:0004843	thiol-dependent ubiquitin-specific protease activity	IEP	Neighborhood
MF	GO:0005488	binding	IEP	Neighborhood
MF	GO:0005524	ATP binding	IEP	Neighborhood
CC	GO:0005634	nucleus	IEP	Neighborhood
BP	GO:0006265	DNA topological change	IEP	Neighborhood
BP	GO:0006325	chromatin organization	IEP	Neighborhood
BP	GO:0006338	chromatin remodeling	IEP	Neighborhood
BP	GO:0006606	protein import into nucleus	IEP	Neighborhood
BP	GO:0006886	intracellular protein transport	IEP	Neighborhood
BP	GO:0006913	nucleocytoplasmic transport	IEP	Neighborhood
BP	GO:0008104	protein localization	IEP	Neighborhood
MF	GO:0008134	transcription factor binding	IEP	Neighborhood
MF	GO:0008144	drug binding	IEP	Neighborhood
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Neighborhood
BP	GO:0009892	negative regulation of metabolic process	IEP	Neighborhood
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Neighborhood
BP	GO:0010629	negative regulation of gene expression	IEP	Neighborhood
BP	GO:0015031	protein transport	IEP	Neighborhood
BP	GO:0015833	peptide transport	IEP	Neighborhood
BP	GO:0016043	cellular component organization	IEP	Neighborhood
MF	GO:0016651	oxidoreductase activity, acting on NAD(P)H	IEP	Neighborhood
MF	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IEP	Neighborhood
MF	GO:0017025	TBP-class protein binding	IEP	Neighborhood
BP	GO:0017038	protein import	IEP	Neighborhood
MF	GO:0017076	purine nucleotide binding	IEP	Neighborhood
MF	GO:0030554	adenyl nucleotide binding	IEP	Neighborhood
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Neighborhood
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Neighborhood
MF	GO:0032553	ribonucleotide binding	IEP	Neighborhood
MF	GO:0032555	purine ribonucleotide binding	IEP	Neighborhood
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Neighborhood
BP	GO:0033036	macromolecule localization	IEP	Neighborhood
BP	GO:0033365	protein localization to organelle	IEP	Neighborhood
BP	GO:0034504	protein localization to nucleus	IEP	Neighborhood
BP	GO:0034613	cellular protein localization	IEP	Neighborhood
MF	GO:0035251	UDP-glucosyltransferase activity	IEP	Neighborhood
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Neighborhood
MF	GO:0036094	small molecule binding	IEP	Neighborhood
BP	GO:0042886	amide transport	IEP	Neighborhood
BP	GO:0043044	ATP-dependent chromatin remodeling	IEP	Neighborhood
MF	GO:0043167	ion binding	IEP	Neighborhood
MF	GO:0043168	anion binding	IEP	Neighborhood
CC	GO:0043226	organelle	IEP	Neighborhood
CC	GO:0043227	membrane-bounded organelle	IEP	Neighborhood
CC	GO:0043229	intracellular organelle	IEP	Neighborhood
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Neighborhood
BP	GO:0045184	establishment of protein localization	IEP	Neighborhood
BP	GO:0045892	negative regulation of transcription, DNA-templated	IEP	Neighborhood
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	IEP	Neighborhood
MF	GO:0046527	glucosyltransferase activity	IEP	Neighborhood
BP	GO:0046907	intracellular transport	IEP	Neighborhood
BP	GO:0048523	negative regulation of cellular process	IEP	Neighborhood
BP	GO:0051169	nuclear transport	IEP	Neighborhood
BP	GO:0051170	import into nucleus	IEP	Neighborhood
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Neighborhood
BP	GO:0051253	negative regulation of RNA metabolic process	IEP	Neighborhood
BP	GO:0051276	chromosome organization	IEP	Neighborhood
BP	GO:0051641	cellular localization	IEP	Neighborhood
BP	GO:0051649	establishment of localization in cell	IEP	Neighborhood
BP	GO:0070727	cellular macromolecule localization	IEP	Neighborhood
BP	GO:0071103	DNA conformation change	IEP	Neighborhood
BP	GO:0071702	organic substance transport	IEP	Neighborhood
BP	GO:0071705	nitrogen compound transport	IEP	Neighborhood
BP	GO:0071840	cellular component organization or biogenesis	IEP	Neighborhood
BP	GO:0072594	establishment of protein localization to organelle	IEP	Neighborhood
MF	GO:0097159	organic cyclic compound binding	IEP	Neighborhood
MF	GO:0097367	carbohydrate derivative binding	IEP	Neighborhood
MF	GO:0101005	ubiquitinyl hydrolase activity	IEP	Neighborhood
MF	GO:1901265	nucleoside phosphate binding	IEP	Neighborhood
MF	GO:1901363	heterocyclic compound binding	IEP	Neighborhood
BP	GO:1902679	negative regulation of RNA biosynthetic process	IEP	Neighborhood
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	IEP	Neighborhood
MF	GO:1990380	Lys48-specific deubiquitinase activity	IEP	Neighborhood
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR019559	Cullin_neddylation_domain	698	758

External Links

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Smo172620

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation