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GO:0004839: ubiquitin activating enzyme activity (Molecular function)

"Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, http://www.bostonbiochem.com/E-301.html, Wikipedia:Ubiquitin-activating_enzyme]


There are 114 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_247 Arabidopsis thaliana 1.85 % 0.005847 0.043884
Cluster_221 Arabidopsis thaliana 0.91 % 0.011886 0.046364
Sequences (114) (download table)

InterPro Domains

GO Terms

Family Terms