GO:0005786: signal recognition particle, endoplasmic reticulum targeting (Cellular component)

"A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732]

There are 1515 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_129 Amborella trichopoda 0.53 % 0.006847 0.032521
Cluster_156 Gingko biloba 2.13 % 0.005676 0.02151
Cluster_350 Zea mays 1.85 % 0.002596 0.013747
Cluster_290 Zea mays 1.41 % 0.003413 0.008316
Cluster_24 Marchantia polymorpha 0.76 % 0.013445 0.039396
Cluster_121 Physcomitrella patens 0.51 % 0.006039 0.019756
Cluster_364 Picea abies 1.49 % 0.00201 0.021306
Cluster_540 Picea abies 1.92 % 0.00156 0.027044
Cluster_316 Oryza sativa 0.99 % 0.004782 0.010973
Cluster_168 Vitis vinifera 1.33 % 0.005685 0.048408
Cluster_81 Chlamydomonas reinhardtii 1.49 % 0.007539 0.035757
Sequences (1515) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms