AT2G16370 (THY-1)

Aliases : THY-1

Description : thymidylate synthase 1

Gene families : OG0004412 (Archaeplastida) Phylogenetic Tree(s): OG0004412_tree ,
OG_05_0004595 (LandPlants) Phylogenetic Tree(s): OG_05_0004595_tree ,
OG_06_0004605 (SeedPlants) Phylogenetic Tree(s): OG_06_0004605_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: AT2G16370
Cluster	HCCA: Cluster_58

Target	Alias	Description	ECC score	Gene Family Method	Actions
Cre17.g715900	No alias	Coenzyme metabolism.tetrahydrofolate...	0.01	Archaeplastida
Gb_18224	No alias	thymidylate synthase. dihydrofolate reductase	0.04	Archaeplastida

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004146	dihydrofolate reductase activity	ISS	Interproscan
MF	GO:0004799	thymidylate synthase activity	ISS	Interproscan
CC	GO:0005575	cellular_component	None	Extended
CC	GO:0005737	cytoplasm	ISM	Interproscan
CC	GO:0005829	cytosol	IDA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006575	cellular modified amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006760	folic acid-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
MF	GO:0008168	methyltransferase activity	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009108	coenzyme biosynthetic process	None	Extended
BP	GO:0009256	10-formyltetrahydrofolate metabolic process	None	Extended
BP	GO:0009257	10-formyltetrahydrofolate biosynthetic process	ISS	Interproscan
BP	GO:0009396	folic acid-containing compound biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
MF	GO:0016740	transferase activity	None	Extended
MF	GO:0016741	transferase activity, transferring one-carbon groups	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0042083	5,10-methylenetetrahydrofolate-dependent methyltransferase activity	None	Extended
BP	GO:0042398	cellular modified amino acid biosynthetic process	None	Extended
BP	GO:0042558	pteridine-containing compound metabolic process	None	Extended
BP	GO:0042559	pteridine-containing compound biosynthetic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0043603	cellular amide metabolic process	None	Extended
BP	GO:0043604	amide biosynthetic process	None	Extended
BP	GO:0043648	dicarboxylic acid metabolic process	None	Extended
BP	GO:0043650	dicarboxylic acid biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
CC	GO:0044424	intracellular part	None	Extended
CC	GO:0044444	cytoplasmic part	None	Extended
CC	GO:0044464	cell part	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046653	tetrahydrofolate metabolic process	None	Extended
BP	GO:0046654	tetrahydrofolate biosynthetic process	None	Extended
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0051188	cofactor biosynthetic process	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000785	chromatin	IEP	Neighborhood
CC	GO:0000786	nucleosome	IEP	Neighborhood
CC	GO:0000790	nuclear chromatin	IEP	Neighborhood
MF	GO:0003678	DNA helicase activity	IEP	Neighborhood
MF	GO:0004003	ATP-dependent DNA helicase activity	IEP	Neighborhood
MF	GO:0004386	helicase activity	IEP	Neighborhood
MF	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IEP	Neighborhood
MF	GO:0005488	binding	IEP	Neighborhood
MF	GO:0005515	protein binding	IEP	Neighborhood
CC	GO:0005634	nucleus	IEP	Neighborhood
CC	GO:0005663	DNA replication factor C complex	IEP	Neighborhood
BP	GO:0006084	acetyl-CoA metabolic process	IEP	Neighborhood
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Neighborhood
BP	GO:0006259	DNA metabolic process	IEP	Neighborhood
BP	GO:0006260	DNA replication	IEP	Neighborhood
BP	GO:0006261	DNA-dependent DNA replication	IEP	Neighborhood
BP	GO:0006268	DNA unwinding involved in DNA replication	IEP	Neighborhood
BP	GO:0006270	DNA replication initiation	IEP	Neighborhood
BP	GO:0006275	regulation of DNA replication	IEP	Neighborhood
BP	GO:0006304	DNA modification	IEP	Neighborhood
BP	GO:0006305	DNA alkylation	IEP	Neighborhood
BP	GO:0006306	DNA methylation	IEP	Neighborhood
BP	GO:0006325	chromatin organization	IEP	Neighborhood
BP	GO:0006342	chromatin silencing	IEP	Neighborhood
BP	GO:0006344	maintenance of chromatin silencing	IEP	Neighborhood
BP	GO:0006346	methylation-dependent chromatin silencing	IEP	Neighborhood
BP	GO:0006349	regulation of gene expression by genetic imprinting	IEP	Neighborhood
BP	GO:0006355	regulation of transcription, DNA-templated	IEP	Neighborhood
BP	GO:0006464	cellular protein modification process	IEP	Neighborhood
BP	GO:0006468	protein phosphorylation	IEP	Neighborhood
BP	GO:0006479	protein methylation	IEP	Neighborhood
BP	GO:0006637	acyl-CoA metabolic process	IEP	Neighborhood
BP	GO:0006996	organelle organization	IEP	Neighborhood
BP	GO:0007346	regulation of mitotic cell cycle	IEP	Neighborhood
MF	GO:0008026	ATP-dependent helicase activity	IEP	Neighborhood
MF	GO:0008094	DNA-dependent ATPase activity	IEP	Neighborhood
BP	GO:0008213	protein alkylation	IEP	Neighborhood
BP	GO:0008283	cell proliferation	IEP	Neighborhood
BP	GO:0009059	macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0009292	genetic transfer	IEP	Neighborhood
BP	GO:0009294	DNA mediated transformation	IEP	Neighborhood
BP	GO:0009658	chloroplast organization	IEP	Neighborhood
BP	GO:0009756	carbohydrate mediated signaling	IEP	Neighborhood
BP	GO:0009889	regulation of biosynthetic process	IEP	Neighborhood
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Neighborhood
BP	GO:0009892	negative regulation of metabolic process	IEP	Neighborhood
BP	GO:0010182	sugar mediated signaling pathway	IEP	Neighborhood
BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IEP	Neighborhood
BP	GO:0010468	regulation of gene expression	IEP	Neighborhood
BP	GO:0010556	regulation of macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0010564	regulation of cell cycle process	IEP	Neighborhood
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Neighborhood
BP	GO:0010608	posttranscriptional regulation of gene expression	IEP	Neighborhood
BP	GO:0010629	negative regulation of gene expression	IEP	Neighborhood
BP	GO:0010638	positive regulation of organelle organization	IEP	Neighborhood
BP	GO:0010639	negative regulation of organelle organization	IEP	Neighborhood
BP	GO:0016043	cellular component organization	IEP	Neighborhood
BP	GO:0016246	RNA interference	IEP	Neighborhood
BP	GO:0016310	phosphorylation	IEP	Neighborhood
BP	GO:0016441	posttranscriptional gene silencing	IEP	Neighborhood
BP	GO:0016458	gene silencing	IEP	Neighborhood
MF	GO:0016462	pyrophosphatase activity	IEP	Neighborhood
BP	GO:0016569	covalent chromatin modification	IEP	Neighborhood
BP	GO:0016570	histone modification	IEP	Neighborhood
BP	GO:0016571	histone methylation	IEP	Neighborhood
BP	GO:0016572	histone phosphorylation	IEP	Neighborhood
MF	GO:0016787	hydrolase activity	IEP	Neighborhood
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Neighborhood
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Neighborhood
MF	GO:0016887	ATPase activity	IEP	Neighborhood
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Neighborhood
BP	GO:0018022	peptidyl-lysine methylation	IEP	Neighborhood
BP	GO:0018193	peptidyl-amino acid modification	IEP	Neighborhood
BP	GO:0018205	peptidyl-lysine modification	IEP	Neighborhood
BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	IEP	Neighborhood
BP	GO:0019222	regulation of metabolic process	IEP	Neighborhood
BP	GO:0019538	protein metabolic process	IEP	Neighborhood
MF	GO:0019899	enzyme binding	IEP	Neighborhood
MF	GO:0019900	kinase binding	IEP	Neighborhood
MF	GO:0019901	protein kinase binding	IEP	Neighborhood
BP	GO:0031047	gene silencing by RNA	IEP	Neighborhood
BP	GO:0031048	chromatin silencing by small RNA	IEP	Neighborhood
BP	GO:0031056	regulation of histone modification	IEP	Neighborhood
BP	GO:0031057	negative regulation of histone modification	IEP	Neighborhood
BP	GO:0031058	positive regulation of histone modification	IEP	Neighborhood
BP	GO:0031060	regulation of histone methylation	IEP	Neighborhood
BP	GO:0031062	positive regulation of histone methylation	IEP	Neighborhood
BP	GO:0031323	regulation of cellular metabolic process	IEP	Neighborhood
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Neighborhood
BP	GO:0031326	regulation of cellular biosynthetic process	IEP	Neighborhood
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Neighborhood
BP	GO:0031399	regulation of protein modification process	IEP	Neighborhood
BP	GO:0031400	negative regulation of protein modification process	IEP	Neighborhood
BP	GO:0031401	positive regulation of protein modification process	IEP	Neighborhood
BP	GO:0032196	transposition	IEP	Neighborhood
BP	GO:0032197	transposition, RNA-mediated	IEP	Neighborhood
BP	GO:0032259	methylation	IEP	Neighborhood
BP	GO:0032269	negative regulation of cellular protein metabolic process	IEP	Neighborhood
BP	GO:0032270	positive regulation of cellular protein metabolic process	IEP	Neighborhood
BP	GO:0032392	DNA geometric change	IEP	Neighborhood
BP	GO:0032508	DNA duplex unwinding	IEP	Neighborhood
CC	GO:0032991	protein-containing complex	IEP	Neighborhood
CC	GO:0032993	protein-DNA complex	IEP	Neighborhood
BP	GO:0033044	regulation of chromosome organization	IEP	Neighborhood
BP	GO:0033865	nucleoside bisphosphate metabolic process	IEP	Neighborhood
BP	GO:0033875	ribonucleoside bisphosphate metabolic process	IEP	Neighborhood
BP	GO:0034032	purine nucleoside bisphosphate metabolic process	IEP	Neighborhood
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0034968	histone lysine methylation	IEP	Neighborhood
BP	GO:0035065	regulation of histone acetylation	IEP	Neighborhood
BP	GO:0035067	negative regulation of histone acetylation	IEP	Neighborhood
BP	GO:0035194	posttranscriptional gene silencing by RNA	IEP	Neighborhood
BP	GO:0035383	thioester metabolic process	IEP	Neighborhood
BP	GO:0036211	protein modification process	IEP	Neighborhood
BP	GO:0040029	regulation of gene expression, epigenetic	IEP	Neighborhood
MF	GO:0042623	ATPase activity, coupled	IEP	Neighborhood
CC	GO:0043227	membrane-bounded organelle	IEP	Neighborhood
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Neighborhood
BP	GO:0043412	macromolecule modification	IEP	Neighborhood
BP	GO:0043414	macromolecule methylation	IEP	Neighborhood
BP	GO:0044030	regulation of DNA methylation	IEP	Neighborhood
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Neighborhood
BP	GO:0044267	cellular protein metabolic process	IEP	Neighborhood
CC	GO:0044422	organelle part	IEP	Neighborhood
CC	GO:0044427	chromosomal part	IEP	Neighborhood
CC	GO:0044446	intracellular organelle part	IEP	Neighborhood
CC	GO:0044454	nuclear chromosome part	IEP	Neighborhood
BP	GO:0044728	DNA methylation or demethylation	IEP	Neighborhood
BP	GO:0044764	multi-organism cellular process	IEP	Neighborhood
CC	GO:0044815	DNA packaging complex	IEP	Neighborhood
BP	GO:0045814	negative regulation of gene expression, epigenetic	IEP	Neighborhood
BP	GO:0045892	negative regulation of transcription, DNA-templated	IEP	Neighborhood
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	IEP	Neighborhood
BP	GO:0048229	gametophyte development	IEP	Neighborhood
BP	GO:0048519	negative regulation of biological process	IEP	Neighborhood
BP	GO:0048523	negative regulation of cellular process	IEP	Neighborhood
BP	GO:0050794	regulation of cellular process	IEP	Neighborhood
BP	GO:0051052	regulation of DNA metabolic process	IEP	Neighborhood
BP	GO:0051129	negative regulation of cellular component organization	IEP	Neighborhood
BP	GO:0051130	positive regulation of cellular component organization	IEP	Neighborhood
BP	GO:0051171	regulation of nitrogen compound metabolic process	IEP	Neighborhood
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Neighborhood
BP	GO:0051247	positive regulation of protein metabolic process	IEP	Neighborhood
BP	GO:0051248	negative regulation of protein metabolic process	IEP	Neighborhood
BP	GO:0051252	regulation of RNA metabolic process	IEP	Neighborhood
BP	GO:0051253	negative regulation of RNA metabolic process	IEP	Neighborhood
BP	GO:0051276	chromosome organization	IEP	Neighborhood
BP	GO:0051567	histone H3-K9 methylation	IEP	Neighborhood
BP	GO:0051570	regulation of histone H3-K9 methylation	IEP	Neighborhood
BP	GO:0051574	positive regulation of histone H3-K9 methylation	IEP	Neighborhood
MF	GO:0060089	molecular transducer activity	IEP	Neighborhood
BP	GO:0060255	regulation of macromolecule metabolic process	IEP	Neighborhood
BP	GO:0061647	histone H3-K9 modification	IEP	Neighborhood
MF	GO:0070035	purine NTP-dependent helicase activity	IEP	Neighborhood
MF	GO:0070182	DNA polymerase binding	IEP	Neighborhood
BP	GO:0071103	DNA conformation change	IEP	Neighborhood
BP	GO:0071514	genetic imprinting	IEP	Neighborhood
BP	GO:0071840	cellular component organization or biogenesis	IEP	Neighborhood
BP	GO:0080090	regulation of primary metabolic process	IEP	Neighborhood
BP	GO:0090239	regulation of histone H4 acetylation	IEP	Neighborhood
BP	GO:0090241	negative regulation of histone H4 acetylation	IEP	Neighborhood
BP	GO:0090304	nucleic acid metabolic process	IEP	Neighborhood
MF	GO:0097472	cyclin-dependent protein kinase activity	IEP	Neighborhood
MF	GO:0140097	catalytic activity, acting on DNA	IEP	Neighborhood
BP	GO:1901983	regulation of protein acetylation	IEP	Neighborhood
BP	GO:1901984	negative regulation of protein acetylation	IEP	Neighborhood
BP	GO:1901987	regulation of cell cycle phase transition	IEP	Neighborhood
BP	GO:1901990	regulation of mitotic cell cycle phase transition	IEP	Neighborhood
BP	GO:1902275	regulation of chromatin organization	IEP	Neighborhood
BP	GO:1902679	negative regulation of RNA biosynthetic process	IEP	Neighborhood
BP	GO:1902749	regulation of cell cycle G2/M phase transition	IEP	Neighborhood
BP	GO:1903506	regulation of nucleic acid-templated transcription	IEP	Neighborhood
BP	GO:1903507	negative regulation of nucleic acid-templated transcription	IEP	Neighborhood
BP	GO:1905268	negative regulation of chromatin organization	IEP	Neighborhood
BP	GO:1905269	positive regulation of chromatin organization	IEP	Neighborhood
BP	GO:2000112	regulation of cellular macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:2000756	regulation of peptidyl-lysine acetylation	IEP	Neighborhood
BP	GO:2000757	negative regulation of peptidyl-lysine acetylation	IEP	Neighborhood
BP	GO:2001141	regulation of RNA biosynthetic process	IEP	Neighborhood
BP	GO:2001251	negative regulation of chromosome organization	IEP	Neighborhood
BP	GO:2001252	positive regulation of chromosome organization	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR023451	Thymidate_synth/dCMP_Mease	239	519
IPR001796	DHFR_dom	23	198

External Links

No external refs found!

AT2G16370 (THY-1)

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation