Gb_18224

Description : thymidylate synthase. dihydrofolate reductase

Gene families : OG0004412 (Archaeplastida) Phylogenetic Tree(s): OG0004412_tree ,
OG_05_0004595 (LandPlants) Phylogenetic Tree(s): OG_05_0004595_tree ,
OG_06_0004605 (SeedPlants) Phylogenetic Tree(s): OG_06_0004605_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: Gb_18224
Cluster	HCCA: Cluster_22

Target	Alias	Description	ECC score	Gene Family Method
AT2G16370	THY-1	thymidylate synthase 1	0.04	Archaeplastida
Cre17.g715900	No alias	Coenzyme metabolism.tetrahydrofolate...	0.1	Archaeplastida
LOC_Os12g26060.1	No alias	thymidylate synthase. dihydrofolate reductase	0.05	Archaeplastida
Solyc01g109830.3.1	No alias	thymidylate synthase. dihydrofolate reductase	0.03	Archaeplastida

Type	GO Term	Name	Evidence	Source
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0004146	dihydrofolate reductase activity	IEA	Interproscan
BP	GO:0006082	organic acid metabolic process	None	Extended
BP	GO:0006575	cellular modified amino acid metabolic process	None	Extended
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006732	coenzyme metabolic process	None	Extended
BP	GO:0006760	folic acid-containing compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009058	biosynthetic process	None	Extended
BP	GO:0009108	coenzyme biosynthetic process	None	Extended
BP	GO:0009396	folic acid-containing compound biosynthetic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016053	organic acid biosynthetic process	None	Extended
MF	GO:0016491	oxidoreductase activity	None	Extended
MF	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	None	Extended
MF	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	None	Extended
BP	GO:0018130	heterocycle biosynthetic process	None	Extended
BP	GO:0019438	aromatic compound biosynthetic process	None	Extended
BP	GO:0019752	carboxylic acid metabolic process	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
BP	GO:0042398	cellular modified amino acid biosynthetic process	None	Extended
BP	GO:0042558	pteridine-containing compound metabolic process	None	Extended
BP	GO:0042559	pteridine-containing compound biosynthetic process	None	Extended
BP	GO:0043436	oxoacid metabolic process	None	Extended
BP	GO:0043603	cellular amide metabolic process	None	Extended
BP	GO:0043604	amide biosynthetic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044249	cellular biosynthetic process	None	Extended
BP	GO:0044271	cellular nitrogen compound biosynthetic process	None	Extended
BP	GO:0044281	small molecule metabolic process	None	Extended
BP	GO:0044283	small molecule biosynthetic process	None	Extended
BP	GO:0046394	carboxylic acid biosynthetic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0046653	tetrahydrofolate metabolic process	None	Extended
BP	GO:0046654	tetrahydrofolate biosynthetic process	IEA	Interproscan
BP	GO:0051186	cofactor metabolic process	None	Extended
BP	GO:0051188	cofactor biosynthetic process	None	Extended
BP	GO:0055114	oxidation-reduction process	IEA	Interproscan
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
BP	GO:1901362	organic cyclic compound biosynthetic process	None	Extended
BP	GO:1901564	organonitrogen compound metabolic process	None	Extended
BP	GO:1901566	organonitrogen compound biosynthetic process	None	Extended
BP	GO:1901576	organic substance biosynthetic process	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	IEP	Neighborhood
CC	GO:0000776	kinetochore	IEP	Neighborhood
MF	GO:0003676	nucleic acid binding	IEP	Neighborhood
MF	GO:0003677	DNA binding	IEP	Neighborhood
MF	GO:0003682	chromatin binding	IEP	Neighborhood
MF	GO:0003774	motor activity	IEP	Neighborhood
MF	GO:0003777	microtubule motor activity	IEP	Neighborhood
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Neighborhood
MF	GO:0003896	DNA primase activity	IEP	Neighborhood
MF	GO:0004518	nuclease activity	IEP	Neighborhood
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Neighborhood
MF	GO:0005488	binding	IEP	Neighborhood
MF	GO:0005515	protein binding	IEP	Neighborhood
MF	GO:0005524	ATP binding	IEP	Neighborhood
CC	GO:0005575	cellular_component	IEP	Neighborhood
CC	GO:0005694	chromosome	IEP	Neighborhood
BP	GO:0006139	nucleobase-containing compound metabolic process	IEP	Neighborhood
BP	GO:0006259	DNA metabolic process	IEP	Neighborhood
BP	GO:0006260	DNA replication	IEP	Neighborhood
BP	GO:0006269	DNA replication, synthesis of RNA primer	IEP	Neighborhood
BP	GO:0006270	DNA replication initiation	IEP	Neighborhood
BP	GO:0006275	regulation of DNA replication	IEP	Neighborhood
BP	GO:0006928	movement of cell or subcellular component	IEP	Neighborhood
BP	GO:0006996	organelle organization	IEP	Neighborhood
BP	GO:0007017	microtubule-based process	IEP	Neighborhood
BP	GO:0007018	microtubule-based movement	IEP	Neighborhood
BP	GO:0007059	chromosome segregation	IEP	Neighborhood
MF	GO:0008017	microtubule binding	IEP	Neighborhood
MF	GO:0008092	cytoskeletal protein binding	IEP	Neighborhood
MF	GO:0008144	drug binding	IEP	Neighborhood
MF	GO:0008168	methyltransferase activity	IEP	Neighborhood
BP	GO:0008608	attachment of spindle microtubules to kinetochore	IEP	Neighborhood
BP	GO:0009059	macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0009262	deoxyribonucleotide metabolic process	IEP	Neighborhood
BP	GO:0009263	deoxyribonucleotide biosynthetic process	IEP	Neighborhood
MF	GO:0015035	protein disulfide oxidoreductase activity	IEP	Neighborhood
MF	GO:0015036	disulfide oxidoreductase activity	IEP	Neighborhood
MF	GO:0015631	tubulin binding	IEP	Neighborhood
MF	GO:0016462	pyrophosphatase activity	IEP	Neighborhood
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Neighborhood
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Neighborhood
MF	GO:0016741	transferase activity, transferring one-carbon groups	IEP	Neighborhood
MF	GO:0016779	nucleotidyltransferase activity	IEP	Neighborhood
MF	GO:0016787	hydrolase activity	IEP	Neighborhood
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	IEP	Neighborhood
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IEP	Neighborhood
MF	GO:0017076	purine nucleotide binding	IEP	Neighborhood
MF	GO:0017111	nucleoside-triphosphatase activity	IEP	Neighborhood
BP	GO:0022402	cell cycle process	IEP	Neighborhood
MF	GO:0030554	adenyl nucleotide binding	IEP	Neighborhood
CC	GO:0031262	Ndc80 complex	IEP	Neighborhood
MF	GO:0032553	ribonucleotide binding	IEP	Neighborhood
MF	GO:0032555	purine ribonucleotide binding	IEP	Neighborhood
MF	GO:0032559	adenyl ribonucleotide binding	IEP	Neighborhood
BP	GO:0032774	RNA biosynthetic process	IEP	Neighborhood
CC	GO:0033643	host cell part	IEP	Neighborhood
CC	GO:0033646	host intracellular part	IEP	Neighborhood
CC	GO:0033647	host intracellular organelle	IEP	Neighborhood
CC	GO:0033648	host intracellular membrane-bounded organelle	IEP	Neighborhood
MF	GO:0034061	DNA polymerase activity	IEP	Neighborhood
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0034654	nucleobase-containing compound biosynthetic process	IEP	Neighborhood
MF	GO:0035639	purine ribonucleoside triphosphate binding	IEP	Neighborhood
MF	GO:0036094	small molecule binding	IEP	Neighborhood
CC	GO:0042025	host cell nucleus	IEP	Neighborhood
MF	GO:0043167	ion binding	IEP	Neighborhood
MF	GO:0043168	anion binding	IEP	Neighborhood
BP	GO:0043170	macromolecule metabolic process	IEP	Neighborhood
CC	GO:0043226	organelle	IEP	Neighborhood
CC	GO:0043228	non-membrane-bounded organelle	IEP	Neighborhood
CC	GO:0043229	intracellular organelle	IEP	Neighborhood
CC	GO:0043232	intracellular non-membrane-bounded organelle	IEP	Neighborhood
CC	GO:0044217	other organism part	IEP	Neighborhood
BP	GO:0044238	primary metabolic process	IEP	Neighborhood
BP	GO:0044260	cellular macromolecule metabolic process	IEP	Neighborhood
CC	GO:0044424	intracellular part	IEP	Neighborhood
CC	GO:0044427	chromosomal part	IEP	Neighborhood
BP	GO:0051052	regulation of DNA metabolic process	IEP	Neighborhood
BP	GO:0051276	chromosome organization	IEP	Neighborhood
BP	GO:0051301	cell division	IEP	Neighborhood
BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	IEP	Neighborhood
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Neighborhood
BP	GO:0090304	nucleic acid metabolic process	IEP	Neighborhood
MF	GO:0097159	organic cyclic compound binding	IEP	Neighborhood
MF	GO:0097367	carbohydrate derivative binding	IEP	Neighborhood
MF	GO:1901265	nucleoside phosphate binding	IEP	Neighborhood
MF	GO:1901363	heterocyclic compound binding	IEP	Neighborhood
BP	GO:1903047	mitotic cell cycle process	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR001796	DHFR_dom	66	242
IPR023451	Thymidate_synth/dCMP_Mease	290	572

External Links

No external refs found!

Gb_18224

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation