Zm00001e023296_P001

Description : DNA topoisomerase (TOP2)

Gene families : OG0003355 (Archaeplastida) Phylogenetic Tree(s): OG0003355_tree ,
OG_05_0004398 (LandPlants) Phylogenetic Tree(s): OG_05_0004398_tree ,
OG_06_0006142 (SeedPlants) Phylogenetic Tree(s): OG_06_0006142_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: Zm00001e023296_P001
Cluster	HCCA: Cluster_115

Target	Alias	Description	ECC score	Gene Family Method
AMTR_s00103p00101630	evm_27.TU.AmTr_v1...	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.14	Archaeplastida
AT3G23890	TOPII, ATTOPII	topoisomerase II	0.22	Archaeplastida
Cpa\|evm.model.tig00021432.55	No alias	DNA topoisomerase 2 OS=Pisum sativum	0.06	Archaeplastida
Cpa\|evm.model.tig00021433.2	No alias	DNA topoisomerase 2 OS=Arabidopsis thaliana	0.04	Archaeplastida
Cre01.g009250	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.09	Archaeplastida
GSVIVT01032138001	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.23	Archaeplastida
Gb_11673	No alias	DNA topoisomerase (TOP2)	0.17	Archaeplastida
Gb_12824	No alias	DNA topoisomerase 2 OS=Pisum sativum (sp\|o24308\|top2_pea : 112.0)	0.15	Archaeplastida
LOC_Os02g47150.1	No alias	DNA topoisomerase (TOP2)	0.19	Archaeplastida
MA_133272g0010	No alias	DNA topoisomerase (TOP2)	0.17	Archaeplastida
MA_6634g0010	No alias	DNA topoisomerase (TOP2)	0.17	Archaeplastida
Mp3g13420.1	No alias	DNA topoisomerase (TOP2)	0.11	Archaeplastida
Pp3c18_20260V3.1	No alias	topoisomerase II	0.11	Archaeplastida
Pp3c19_3610V3.1	No alias	topoisomerase II	0.08	Archaeplastida
Smo127267	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.12	Archaeplastida
Smo98330	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.1	Archaeplastida
Solyc01g087500.3.1	No alias	DNA topoisomerase (TOP2)	0.15	Archaeplastida

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
MF	GO:0061505	DNA topoisomerase II activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
CC	GO:0000148	1,3-beta-D-glucan synthase complex	IEP	Neighborhood
CC	GO:0000151	ubiquitin ligase complex	IEP	Neighborhood
CC	GO:0000152	nuclear ubiquitin ligase complex	IEP	Neighborhood
BP	GO:0000723	telomere maintenance	IEP	Neighborhood
CC	GO:0000776	kinetochore	IEP	Neighborhood
CC	GO:0000796	condensin complex	IEP	Neighborhood
MF	GO:0003682	chromatin binding	IEP	Neighborhood
MF	GO:0003690	double-stranded DNA binding	IEP	Neighborhood
MF	GO:0003774	motor activity	IEP	Neighborhood
MF	GO:0003777	microtubule motor activity	IEP	Neighborhood
MF	GO:0003843	1,3-beta-D-glucan synthase activity	IEP	Neighborhood
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Neighborhood
MF	GO:0003909	DNA ligase activity	IEP	Neighborhood
MF	GO:0003910	DNA ligase (ATP) activity	IEP	Neighborhood
MF	GO:0003950	NAD+ ADP-ribosyltransferase activity	IEP	Neighborhood
MF	GO:0004518	nuclease activity	IEP	Neighborhood
MF	GO:0005515	protein binding	IEP	Neighborhood
CC	GO:0005634	nucleus	IEP	Neighborhood
CC	GO:0005680	anaphase-promoting complex	IEP	Neighborhood
CC	GO:0005694	chromosome	IEP	Neighborhood
BP	GO:0006074	(1->3)-beta-D-glucan metabolic process	IEP	Neighborhood
BP	GO:0006075	(1->3)-beta-D-glucan biosynthetic process	IEP	Neighborhood
BP	GO:0006260	DNA replication	IEP	Neighborhood
BP	GO:0006270	DNA replication initiation	IEP	Neighborhood
BP	GO:0006281	DNA repair	IEP	Neighborhood
BP	GO:0006298	mismatch repair	IEP	Neighborhood
BP	GO:0006310	DNA recombination	IEP	Neighborhood
BP	GO:0006323	DNA packaging	IEP	Neighborhood
BP	GO:0006338	chromatin remodeling	IEP	Neighborhood
BP	GO:0006471	protein ADP-ribosylation	IEP	Neighborhood
BP	GO:0006928	movement of cell or subcellular component	IEP	Neighborhood
BP	GO:0006950	response to stress	IEP	Neighborhood
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Neighborhood
BP	GO:0007017	microtubule-based process	IEP	Neighborhood
BP	GO:0007018	microtubule-based movement	IEP	Neighborhood
BP	GO:0007076	mitotic chromosome condensation	IEP	Neighborhood
MF	GO:0008017	microtubule binding	IEP	Neighborhood
MF	GO:0008092	cytoskeletal protein binding	IEP	Neighborhood
BP	GO:0010639	negative regulation of organelle organization	IEP	Neighborhood
MF	GO:0015631	tubulin binding	IEP	Neighborhood
MF	GO:0016763	transferase activity, transferring pentosyl groups	IEP	Neighborhood
MF	GO:0016886	ligase activity, forming phosphoric ester bonds	IEP	Neighborhood
BP	GO:0022402	cell cycle process	IEP	Neighborhood
BP	GO:0030261	chromosome condensation	IEP	Neighborhood
MF	GO:0030983	mismatched DNA binding	IEP	Neighborhood
CC	GO:0031262	Ndc80 complex	IEP	Neighborhood
CC	GO:0031461	cullin-RING ubiquitin ligase complex	IEP	Neighborhood
MF	GO:0031491	nucleosome binding	IEP	Neighborhood
BP	GO:0032200	telomere organization	IEP	Neighborhood
BP	GO:0033043	regulation of organelle organization	IEP	Neighborhood
BP	GO:0033044	regulation of chromosome organization	IEP	Neighborhood
BP	GO:0033554	cellular response to stress	IEP	Neighborhood
MF	GO:0034061	DNA polymerase activity	IEP	Neighborhood
CC	GO:0042555	MCM complex	IEP	Neighborhood
BP	GO:0042592	homeostatic process	IEP	Neighborhood
BP	GO:0043044	ATP-dependent chromatin remodeling	IEP	Neighborhood
BP	GO:0043086	negative regulation of catalytic activity	IEP	Neighborhood
CC	GO:0043226	organelle	IEP	Neighborhood
CC	GO:0043227	membrane-bounded organelle	IEP	Neighborhood
CC	GO:0043229	intracellular organelle	IEP	Neighborhood
CC	GO:0043231	intracellular membrane-bounded organelle	IEP	Neighborhood
BP	GO:0044092	negative regulation of molecular function	IEP	Neighborhood
CC	GO:0044424	intracellular part	IEP	Neighborhood
CC	GO:0044427	chromosomal part	IEP	Neighborhood
CC	GO:0044464	cell part	IEP	Neighborhood
MF	GO:0044877	protein-containing complex binding	IEP	Neighborhood
BP	GO:0051095	regulation of helicase activity	IEP	Neighborhood
BP	GO:0051097	negative regulation of helicase activity	IEP	Neighborhood
BP	GO:0051128	regulation of cellular component organization	IEP	Neighborhood
BP	GO:0051129	negative regulation of cellular component organization	IEP	Neighborhood
BP	GO:0051336	regulation of hydrolase activity	IEP	Neighborhood
BP	GO:0051346	negative regulation of hydrolase activity	IEP	Neighborhood
BP	GO:0051716	cellular response to stimulus	IEP	Neighborhood
BP	GO:0060249	anatomical structure homeostasis	IEP	Neighborhood
CC	GO:1902494	catalytic complex	IEP	Neighborhood
BP	GO:1903047	mitotic cell cycle process	IEP	Neighborhood
BP	GO:1905462	regulation of DNA duplex unwinding	IEP	Neighborhood
BP	GO:1905463	negative regulation of DNA duplex unwinding	IEP	Neighborhood
BP	GO:1905774	regulation of DNA helicase activity	IEP	Neighborhood
BP	GO:1905775	negative regulation of DNA helicase activity	IEP	Neighborhood
CC	GO:1990234	transferase complex	IEP	Neighborhood
BP	GO:2001251	negative regulation of chromosome organization	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR031660	TOPRIM_C	562	688
IPR003594	HATPase_C	69	216
IPR006171	TOPRIM_domain	448	546
IPR002205	Topo_IIA_A/C	691	1150
IPR013506	Topo_IIA_bsu_dom2	262	410

External Links

No external refs found!

Zm00001e023296_P001

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation