MA_133272g0010

Description : DNA topoisomerase (TOP2)

Gene families : OG0003355 (Archaeplastida) Phylogenetic Tree(s): OG0003355_tree ,
OG_05_0004398 (LandPlants) Phylogenetic Tree(s): OG_05_0004398_tree ,
OG_06_0006142 (SeedPlants) Phylogenetic Tree(s): OG_06_0006142_tree

Sequence : coding (download), protein (download)

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Note:Only the main profile, including all conditions, is shown. Additional statistics and tissue specific profiles are available here.

Type	Description	Actions
Neighborhood	HRR: MA_133272g0010
Cluster	HCCA: Cluster_194

Target	Alias	Description	ECC score	Gene Family Method
AMTR_s00103p00101630	evm_27.TU.AmTr_v1...	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.1	Archaeplastida
AT3G23890	TOPII, ATTOPII	topoisomerase II	0.14	Archaeplastida
Cpa\|evm.model.tig00021432.55	No alias	DNA topoisomerase 2 OS=Pisum sativum	0.06	Archaeplastida
Cpa\|evm.model.tig00021433.2	No alias	DNA topoisomerase 2 OS=Arabidopsis thaliana	0.04	Archaeplastida
Cre01.g009250	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.09	Archaeplastida
GSVIVT01032138001	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.15	Archaeplastida
Gb_11673	No alias	DNA topoisomerase (TOP2)	0.18	Archaeplastida
Gb_12824	No alias	DNA topoisomerase 2 OS=Pisum sativum (sp\|o24308\|top2_pea : 112.0)	0.18	Archaeplastida
LOC_Os02g47150.1	No alias	DNA topoisomerase (TOP2)	0.07	Archaeplastida
Mp3g13420.1	No alias	DNA topoisomerase (TOP2)	0.09	Archaeplastida
Pp3c18_20260V3.1	No alias	topoisomerase II	0.05	Archaeplastida
Pp3c19_3610V3.1	No alias	topoisomerase II	0.09	Archaeplastida
Smo127267	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.07	Archaeplastida
Smo98330	No alias	Cell cycle.interphase.DNA replication.preinitiation.TOP2...	0.05	Archaeplastida
Solyc01g087500.3.1	No alias	DNA topoisomerase (TOP2)	0.12	Archaeplastida
Zm00001e015542_P001	No alias	DNA topoisomerase (TOP2)	0.17	Archaeplastida
Zm00001e023296_P001	No alias	DNA topoisomerase (TOP2)	0.17	Archaeplastida

Type	GO Term	Name	Evidence	Source
MF	GO:0000166	nucleotide binding	None	Extended
MF	GO:0003674	molecular_function	None	Extended
MF	GO:0003676	nucleic acid binding	None	Extended
MF	GO:0003677	DNA binding	IEA	Interproscan
MF	GO:0003824	catalytic activity	None	Extended
MF	GO:0003916	DNA topoisomerase activity	None	Extended
MF	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity	IEA	Interproscan
MF	GO:0005488	binding	None	Extended
MF	GO:0005524	ATP binding	IEA	Interproscan
BP	GO:0006139	nucleobase-containing compound metabolic process	None	Extended
BP	GO:0006259	DNA metabolic process	None	Extended
BP	GO:0006265	DNA topological change	IEA	Interproscan
BP	GO:0006725	cellular aromatic compound metabolic process	None	Extended
BP	GO:0006807	nitrogen compound metabolic process	None	Extended
BP	GO:0006996	organelle organization	None	Extended
MF	GO:0008094	DNA-dependent ATPase activity	None	Extended
MF	GO:0008144	drug binding	None	Extended
BP	GO:0008150	biological_process	None	Extended
BP	GO:0008152	metabolic process	None	Extended
BP	GO:0009987	cellular process	None	Extended
BP	GO:0016043	cellular component organization	None	Extended
MF	GO:0016462	pyrophosphatase activity	None	Extended
MF	GO:0016787	hydrolase activity	None	Extended
MF	GO:0016817	hydrolase activity, acting on acid anhydrides	None	Extended
MF	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	None	Extended
MF	GO:0016853	isomerase activity	None	Extended
MF	GO:0016887	ATPase activity	None	Extended
MF	GO:0017076	purine nucleotide binding	None	Extended
MF	GO:0017111	nucleoside-triphosphatase activity	None	Extended
MF	GO:0030554	adenyl nucleotide binding	None	Extended
MF	GO:0032553	ribonucleotide binding	None	Extended
MF	GO:0032555	purine ribonucleotide binding	None	Extended
MF	GO:0032559	adenyl ribonucleotide binding	None	Extended
BP	GO:0034641	cellular nitrogen compound metabolic process	None	Extended
MF	GO:0035639	purine ribonucleoside triphosphate binding	None	Extended
MF	GO:0036094	small molecule binding	None	Extended
MF	GO:0042623	ATPase activity, coupled	None	Extended
MF	GO:0043167	ion binding	None	Extended
MF	GO:0043168	anion binding	None	Extended
BP	GO:0043170	macromolecule metabolic process	None	Extended
BP	GO:0044237	cellular metabolic process	None	Extended
BP	GO:0044238	primary metabolic process	None	Extended
BP	GO:0044260	cellular macromolecule metabolic process	None	Extended
BP	GO:0046483	heterocycle metabolic process	None	Extended
BP	GO:0051276	chromosome organization	None	Extended
MF	GO:0061505	DNA topoisomerase II activity	None	Extended
BP	GO:0071103	DNA conformation change	None	Extended
BP	GO:0071704	organic substance metabolic process	None	Extended
BP	GO:0071840	cellular component organization or biogenesis	None	Extended
BP	GO:0090304	nucleic acid metabolic process	None	Extended
MF	GO:0097159	organic cyclic compound binding	None	Extended
MF	GO:0097367	carbohydrate derivative binding	None	Extended
MF	GO:0140097	catalytic activity, acting on DNA	None	Extended
MF	GO:1901265	nucleoside phosphate binding	None	Extended
BP	GO:1901360	organic cyclic compound metabolic process	None	Extended
MF	GO:1901363	heterocyclic compound binding	None	Extended

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Type	GO Term	Name	Evidence	Source
MF	GO:0003678	DNA helicase activity	IEP	Neighborhood
MF	GO:0003774	motor activity	IEP	Neighborhood
MF	GO:0003777	microtubule motor activity	IEP	Neighborhood
MF	GO:0003887	DNA-directed DNA polymerase activity	IEP	Neighborhood
MF	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEP	Neighborhood
MF	GO:0005515	protein binding	IEP	Neighborhood
CC	GO:0005634	nucleus	IEP	Neighborhood
CC	GO:0005694	chromosome	IEP	Neighborhood
BP	GO:0006260	DNA replication	IEP	Neighborhood
BP	GO:0006270	DNA replication initiation	IEP	Neighborhood
BP	GO:0006275	regulation of DNA replication	IEP	Neighborhood
BP	GO:0006928	movement of cell or subcellular component	IEP	Neighborhood
BP	GO:0006974	cellular response to DNA damage stimulus	IEP	Neighborhood
BP	GO:0007017	microtubule-based process	IEP	Neighborhood
BP	GO:0007018	microtubule-based movement	IEP	Neighborhood
MF	GO:0008017	microtubule binding	IEP	Neighborhood
MF	GO:0008092	cytoskeletal protein binding	IEP	Neighborhood
BP	GO:0008156	negative regulation of DNA replication	IEP	Neighborhood
BP	GO:0009058	biosynthetic process	IEP	Neighborhood
BP	GO:0009059	macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0009890	negative regulation of biosynthetic process	IEP	Neighborhood
BP	GO:0009892	negative regulation of metabolic process	IEP	Neighborhood
BP	GO:0010558	negative regulation of macromolecule biosynthetic process	IEP	Neighborhood
BP	GO:0010605	negative regulation of macromolecule metabolic process	IEP	Neighborhood
MF	GO:0015631	tubulin binding	IEP	Neighborhood
MF	GO:0016725	oxidoreductase activity, acting on CH or CH2 groups	IEP	Neighborhood
MF	GO:0016728	oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	IEP	Neighborhood
MF	GO:0016779	nucleotidyltransferase activity	IEP	Neighborhood
BP	GO:0031324	negative regulation of cellular metabolic process	IEP	Neighborhood
BP	GO:0031327	negative regulation of cellular biosynthetic process	IEP	Neighborhood
BP	GO:0033554	cellular response to stress	IEP	Neighborhood
CC	GO:0033643	host cell part	IEP	Neighborhood
CC	GO:0033646	host intracellular part	IEP	Neighborhood
CC	GO:0033647	host intracellular organelle	IEP	Neighborhood
CC	GO:0033648	host intracellular membrane-bounded organelle	IEP	Neighborhood
MF	GO:0034061	DNA polymerase activity	IEP	Neighborhood
BP	GO:0034645	cellular macromolecule biosynthetic process	IEP	Neighborhood
CC	GO:0042025	host cell nucleus	IEP	Neighborhood
MF	GO:0043138	3'-5' DNA helicase activity	IEP	Neighborhood
CC	GO:0043226	organelle	IEP	Neighborhood
CC	GO:0043229	intracellular organelle	IEP	Neighborhood
CC	GO:0044217	other organism part	IEP	Neighborhood
BP	GO:0044249	cellular biosynthetic process	IEP	Neighborhood
BP	GO:0045005	DNA-dependent DNA replication maintenance of fidelity	IEP	Neighborhood
BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	IEP	Neighborhood
BP	GO:0048478	replication fork protection	IEP	Neighborhood
BP	GO:0048523	negative regulation of cellular process	IEP	Neighborhood
BP	GO:0051052	regulation of DNA metabolic process	IEP	Neighborhood
BP	GO:0051053	negative regulation of DNA metabolic process	IEP	Neighborhood
BP	GO:0051172	negative regulation of nitrogen compound metabolic process	IEP	Neighborhood
BP	GO:0051716	cellular response to stimulus	IEP	Neighborhood
MF	GO:0061731	ribonucleoside-diphosphate reductase activity	IEP	Neighborhood
BP	GO:0090329	regulation of DNA-dependent DNA replication	IEP	Neighborhood
BP	GO:1901576	organic substance biosynthetic process	IEP	Neighborhood
BP	GO:2000104	negative regulation of DNA-dependent DNA replication	IEP	Neighborhood
BP	GO:2000113	negative regulation of cellular macromolecule biosynthetic process	IEP	Neighborhood

InterPro domains	Description	Start	Stop
IPR003594	HATPase_C	10	154
IPR006171	TOPRIM_domain	388	486
IPR002205	Topo_IIA_A/C	625	1085
IPR031660	TOPRIM_C	502	622
IPR013506	Topo_IIA_bsu_dom2	202	357

External Links

No external refs found!

MA_133272g0010

Expression Profile

Co-expression Networks

Expression Context Conservation (ECC)

Functional Annotation