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GO:0016592: mediator complex (Cellular component)

"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


There are 4766 sequences with this label.

Enriched clusters
Name Species % in cluster p-value corrected p-value action
Cluster_139 Arabidopsis thaliana 2.2 % 0.004387 0.030893
Cluster_221 Arabidopsis thaliana 1.82 % 0.006342 0.030388
Cluster_131 Arabidopsis thaliana 3.45 % 0.000115 0.014543
Cluster_27 Amborella trichopoda 0.93 % 0.006882 0.043331
Cluster_172 Amborella trichopoda 0.87 % 0.007773 0.047749
Cluster_116 Gingko biloba 0.97 % 0.001596 0.007779
Cluster_61 Zea mays 1.86 % 2e-06 7.4e-05
Cluster_310 Zea mays 1.82 % 0.000919 0.023815
Cluster_262 Zea mays 1.64 % 0.001128 0.020415
Cluster_125 Marchantia polymorpha 3.16 % 3.1e-05 0.001784
Cluster_178 Physcomitrella patens 1.82 % 0.010125 0.016664
Cluster_208 Picea abies 1.16 % 0.01538 0.038175
Cluster_511 Picea abies 1.64 % 0.010932 0.027858
Cluster_293 Oryza sativa 1.32 % 0.001875 0.009251
Cluster_40 Oryza sativa 1.52 % 7.9e-05 0.002261
Cluster_217 Solanum lycopersicum 3.95 % 3.4e-05 0.00307
Cluster_28 Chlamydomonas reinhardtii 0.93 % 0.002104 0.020106
Cluster_50 Chlamydomonas reinhardtii 2.0 % 0.016794 0.040359
Sequences (4766) (download table)

Info: GO-associations disabled for items with more than 300 associated sequences !
InterPro Domains

Family Terms